Advancing excellence in laboratory medicine for better healthcare worldwide

Key Publications on Biochemical Monitoring

 

Disclaimer: This collection of resources on this webpage reflects a rapidly changing situation and due to the need for quick answers during the COVID-19 pandemic, we acknowledge that most fast-tracked publications are based on observations, often on a small number of cases, which would be considered as preliminary evidence. The IFCC Task Force has not critically appraised all resources cited here for scientific validity but tried to present information that is believed to help laboratory professionals in formulating their local policies in a more informed manner. The interim advice or conclusions presented here may change as more information is gathered.

 

 

 

 

General

  1. Henry BM, de Oliveira MH, Benoit S, Plebani M, Lippi G.Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clinical Chemistry and Laboratory Medicine (CCLM). 2020 Apr 10;1(ahead-of-print). PMID:32286245
  2. Lippi G, Plebani M. Laboratory abnormalities in patients with COVID-2019 infection. Clinical Chemistry and Laboratory Medicine (CCLM). 2020 Mar 3. PMID:32119647
  3. Lippi G, Plebani M. The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Clinical Chemistry and Laboratory Medicine (CCLM). 2020 Mar 19. PMID:32191623
  4. Gao Y, Li T, Han M, Li X, Wu D, Xu Y, Zhu Y, Liu Y, Wang X, Wang L. Diagnostic Utility of Clinical Laboratory Data Determinations for Patients with the Severe COVID‐ Journal of Medical Virology. 2020 Mar 17. PMID: 32181911
  5. Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP, Alvarado-Arnez LE, Bonilla-Aldana DK, Franco-Paredes C, Henao-Martinez AF, Paniz-Mondolfi A. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Medicine and Infectious Disease. 2020 Mar 13:101623. PMID: 32179124
  6. Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Medicine. 2020 Mar 3:1-3. PMID:32125452
  7. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020 Mar 11. PMID:32171076
  8. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DS, Du B. Clinical characteristics of coronavirus disease 2019 in China. New England Journal of Medicine. 2020 Feb 28. PMID: 32109013
  9. Kavsak PA, de Wit K, Worster A. Clinical chemistry tests for patients with COVID-19–important caveats for interpretation. Clinical Chemistry and Laboratory Medicine (CCLM). 2020 Apr 16;1(ahead-of-print). PMID: 32301748
  10. Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J, Wang Z, Li J, Li J, Feng C, Zhang Z. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Science China Life Sciences. 2020 Mar;63(3):364-74. PMID:32048163
  11. Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB.Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020 Apr 13.PMID:32282022
  12. Ferrari D, Motta A, Strollo M, Banfi G, Locatelli M. Routine blood tests as a potential diagnostic tool for COVID-19. Clinical Chemistry and Laboratory Medicine (CCLM). 2020 Apr 16;1(ahead-of-print). PMID: 32301746
  13. Lippi G, South AM, Henry BM. ANNALS EXPRESS: Electrolyte Imbalances in Patients with Severe Coronavirus Disease 2019 (COVID-19. Ann Clin Biochem. 2020 Apr 8 (ahead-of-print). PMID: 32266828
  14. Nichols JH, Rauch CA. A Laboratory Risk Assessment during the Coronavirus (COVID-19) Pandemic. The Journal of Applied Laboratory Medicine. 2020 Apr 16. PMCID: PMC7184397
  15. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, Barnaby DP, Becker LB, Chelico JD, Cohen SL, Cookingham J. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020 Apr 22. PMID: 32320003
  16. Kavsak PA, de Wit K, Worster A. Emerging key laboratory tests for patients with COVID-19. Clinical Biochemistry. 2020 Apr 30. PMID: 32360478
  17. Lu G, Wang J. Dynamic changes in routine blood parameters of a severe COVID-19 case. Clinica Chimica Acta. 2020 May 13. PMID: 32405079
  18. Zhu L, She ZG, Cheng X, Qin JJ, Zhang XJ, Cai J, Lei F, Wang H, Xie J, Wang W, Li H, Zhang P, Song X, Chen X, Xiang M, Zhang C, Bai L, Xiang D, Chen MM, Liu Y, Yan Y, Liu M, Mao W, Zou J, Liu L, Chen G, Luo P, Xiao B, Zhang C, Zhang Z, Lu Z, Wang J, Lu H, Xia X, Wang D, Liao X, Peng G, Ye P, Yang J, Yuan Y, Huang X, Guo J, Zhang BH, Li H. Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes. Cell Metab. 2020 Jun 2;31(6):1068-1077.e3. doi: 10.1016/j.cmet.2020.04.021. Epub 2020 May 1. PMID: 32369736
  19. Wang M, Zhang J, Ye D, et al. Time-dependent changes in the clinical characteristics and prognosis of hospitalized COVID-19 patients in Wuhan, China: A retrospective study [published online ahead of print, 2020 Jul 6]. Clin Chim Acta. 2020;510:220-227. doi:10.1016/j.cca.2020.06.051
  20. Yang HS, Hou Y, Vasovic LV, et al. Routine laboratory blood tests predict SARS-CoV-2 infection using machine learning [published online ahead of print, 2020 Aug 21].Clin Chem. 2020;hvaa200. doi:10.1093/clinchem/hvaa200
  21. Panteghini M. Lactate dehydrogenase: an old enzyme reborn as a COVID-19 marker (and not only) [published online ahead of print, 2020 Aug 24].Clin Chem Lab Med. 2020;/j/cclm.ahead-of-print/cclm-2020-1062/cclm-2020-1062.xml. doi:10.1515/cclm-2020-1062
  22. Novelli A, Andreani M, Biancolella M, Liberatoscioli L, Passarelli C, Colona VL, Rogliani P, Leonardis F, Campana A, Carsetti R, Andreoni M, Bernardini S, Novelli G, Locatelli F. HLA allele frequencies and susceptibility to COVID-19 in a group of 99 Italian patients. 2020 Aug 22:10.1111/tan.14047. doi: 10.1111/tan.14047. Epub ahead of print. PMID: 32827207; PMCID: PMC7461491.
  23. Latini A, Agolini E, Novelli A, Borgiani P, Giannini R, Gravina P, Smarrazzo A, Dauri M, Andreoni M, Rogliani P, Bernardini S, Helmer-Citterich M, Biancolella M, Novelli G. COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells. Genes (Basel). 2020 Aug 27;11(9):E1010. doi: 10.3390/genes11091010. PMID: 32867305.
  24. Moreno-Pérez O, Leon-Ramirez JM, Fuertes-Kenneally L, Perdiguero M, Andres M, Garcia-Navarro M, Ruiz-Torregrosa P, Boix V, Gil J, Merino E; COVID19-ALC research group. Hypokalemia as a sensitive biomarker of disease severity and invasive mechanical ventilation requirement in COVID-19 pneumonia: a case series of 306 Mediterranean patients. Int J Infect Dis. 2020 Sep 17:S1201-9712(20)30749-9. doi: 10.1016/j.ijid.2020.09.033. Epub ahead of print. PMID: 32950739.
  25. Liu J, Liu Z, Jiang W, Wang J, Zhu M, Song J, Wang X, Su Y, Xiang G, Ye M, Li J, Zhang Y, Shen Q, Li Z, Yao D, Song Y, Yu K, Luo Z, Ye L. Clinical Predictors of COVID-19 Disease Progression and Death: Analysis of 214 Hospitalized Patients from Wuhan, China. Clin Respir J. 2020 Oct 22. doi: 10.1111/crj.13296. Epub ahead of print. PMID: 33090710.
  26. Zeng HL, Lu QB, Yang Q, Wang X, Yue DY, Zhang LK, Li H, Liu W, Li HJ. Longitudinal Profile of Laboratory Parameters and Their Application in the Prediction for Fatal Outcome Among Patients Infected With SARS-CoV-2: A Retrospective Cohort Study. Clin Infect Dis. 2020 Oct 13:ciaa574. doi: 10.1093/cid/ciaa574. Epub ahead of print. PMID: 33048116.
  27. Stegeman I, Ochodo EA, Guleid F, Holtman GA, Yang B, Davenport C, Deeks JJ, Dinnes J, Dittrich S, Emperador D, Hooft L, Spijker R, Takwoingi Y, Van den Bruel A, Wang J, Langendam M, Verbakel JY, Leeflang MM; Cochrane COVID-19 Diagnostic Test Accuracy Group. Routine laboratory testing to determine if a patient has COVID-19. Cochrane Database Syst Rev. 2020 Nov 19;11:CD013787. doi: 10.1002/14651858.CD013787. PMID: 33211319.
  28. Kiss S, Gede N, Hegyi P, Németh D, Földi M, Dembrovszky F, Nagy B, Juhász MF, Ocskay K, Zádori N, Molnár Z, Párniczky A, Hegyi PJ, Szakács Z, Pár G, Erőss B, Alizadeh H. Early changes in laboratory parameters are predictors of mortality and ICU admission in patients with COVID-19: a systematic review and meta-analysis. Med Microbiol Immunol. 2020 Nov 21. doi: 10.1007/s00430-020-00696-w. Epub ahead of print. PMID: 33219397.
  29. Mishra T, Wang M, Metwally AA, Bogu GK, Brooks AW, Bahmani A, Alavi A, Celli A, Higgs E, Dagan-Rosenfeld O, Fay B, Kirkpatrick S, Kellogg R, Gibson M, Wang T, Hunting EM, Mamic P, Ganz AB, Rolnik B, Li X, Snyder MP. Pre-symptomatic detection of COVID-19 from smartwatch data. Nat Biomed Eng. 2020 Nov 18. doi: 10.1038/s41551-020-00640-6. Epub ahead of print. PMID: 33208926.

 

 

 

 

 

Inflammatory Markers:

  1. Lippi G, Plebani M. Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis. Clinica chimica acta; international journal of clinical chemistry. 2020 Mar 4. PMID:32145275
  2. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. The Lancet. 2020 Mar 16. PMID:32192578
  3. Monteleone G, Sarzi-Puttini PC, Ardizzone S. Preventing COVID-19-induced pneumonia with anticytokine therapy. The Lancet Rheumatology. 2020 Apr 6. PMID: TBD
  4. McGonagle D, Sharif K, O'Regan A, Bridgewood C. Interleukin-6 use in COVID-19 pneumonia related macrophage activation syndrome. Autoimmunity Reviews. 2020 Apr 3:102537. PMID: 32251717
  5. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y.Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. Jama. 2020 Mar 17;323(11):1061-9. PMID: 32031570
  6. Chen X, Zhao B, Qu Y, Chen Y, Xiong J, Feng Y, Men D, Huang Q, Liu Y, Yang B, Ding J. Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. Clinical Infectious Diseases. 2020 Apr 17. PMID: 32301997
  7. Zhao Y, Qin L, Zhang P, Li K, Liang L, Sun J, Xu B, Dai Y, Li X, Zhang C, Peng Y. Longitudinal Profiling of Cytokines and Chemokines in COVID-19 Reveals Inhibitory Mediators IL-1Ra and IL-10 Are Associated with Disease Severity While Elevated RANTES Is an Early Predictor of Mild Disease. Non-peer reviewed preprint.
  8. Liu F, Li L, Xu M, Wu J, Luo D, Zhu Y, Li B, Song X, Zhou X. Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19. Journal of Clinical Virology. 2020 Apr 14:104370. PMID: 32344321
  9. Aziz M, Fatima R, Assaly R. Elevated Interleukin‐6 and Severe COVID‐19: A Meta‐ Journal of Medical Virology. 2020 Apr 28. PMID: 32343429
  10. Lapić I, Rogić D, Plebani M. Erythrocyte sedimentation rate is associated with severe coronavirus disease 2019 (COVID-19): a pooled analysis. Clinical chemistry and laboratory medicine. 2020 May 9. PMID: 32386190
  11. Del Valle et al. An inflammatory cytokine signature helps predict COVID-19 severity and death. https://doi.org/10.1101/2020.05.28.20115758
  12. Ognibene A, Lorubbio M, Magliocca P, Tripodo E, Vaggelli G, Iannelli G, Feri M, Scala R, Tartaglia AP, Galano A, Pancrazzi A. ELEVATED MONOCYTE DISTRIBUTION WIDTH IN COVID-19 PATIENTS: THE CONTRIBUTION OF THE NOVEL SEPSIS INDICATOR. Clinica Chimica Acta. 2020 Jun 3. PMID: 32504637
  13. Chi Y, Ge Y, Wu B, Zhang W, Wu T, Wen T, Liu J, Guo X, Huang C, Jiao Y, Zhu F, Zhu B, Cui L. Serum Cytokine and Chemokine profile in Relation to the Severity of Coronavirus disease 2019 (COVID-19) in China. J Infect Dis. 2020 Jun 21:jiaa363. doi: 10.1093/infdis/jiaa363. Epub ahead of print. PMID: 32563194.
  14. Spectrum of innate and adaptive immune response to SARS CoV 2 infection across asymptomatic, mild and severe cases; a longitudinal cohort study. https://doi.org/10.1101/2020.06.22.20137141
  15. Long QX, Tang XJ, Shi QL, Li Q, Deng HJ, Yuan J, Hu JL, Xu W, Zhang Y, Lv FJ, Su K. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nature Medicine. 2020 Jun 18:1-5. https://doi.org/10.1038/s41591-020-0965-6
  16. Pfaar O, Torres MJ, Akdis CA. COVID-19: A series of important recent clinical and laboratory reports in immunology and pathogenesis of SARS-CoV-2 infection and care of allergy patients [published online ahead of print, 2020 Jun 26]. Allergy. 2020;10.1111/all.14472. doi:10.1111/all.14472
  17. Gupta A, Madhavan MV, Sehgal K, et al. Extrapulmonary manifestations of COVID-19 [published online ahead of print, 2020 Jul 10]. Nat Med. 2020;10.1038/s41591-020-0968-3. doi:10.1038/s41591-020-0968-3
  18. Rocio LG, Alberto UR, Paloma T, et al. Interleukin-6-based mortality risk model for hospitalised COVID-19 patients [published online ahead of print, 2020 Jul 22]. J Allergy Clin Immunol. 2020;S0091-6749(20)31027-7. doi:10.1016/j.jaci.2020.07.009
  19. Zhang D, Zhou X, Yan S, et al. Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU [published online ahead of print, 2020 Jul 6]. Clin Chim Acta. 2020;510:47-53. doi:10.1016/j.cca.2020.07.002
  20. Hu D, Li L, Shi W, Zhang L. Less expression of CD4+and CD8+ T cells might reflect the severity of infection and predict worse prognosis in patients with COVID-19: Evidence from a pooled analysis [published online ahead of print, 2020 Jun 27]. Clin Chim Acta. 2020;510:1-4. doi:10.1016/j.cca.2020.06.040
  21. Del Valle DM, Kim-Schulze S, Huang HH, et al. An inflammatory cytokine signature predicts COVID-19 severity and survival [published online ahead of print, 2020 Aug 24].Nat Med. 2020;10.1038/s41591-020-1051-9. doi:10.1038/s41591-020-1051-9
  22. Buszko M, Park JH, Verthelyi D, Sen R, Young HA, Rosenberg AS. The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge [published online ahead of print, 2020 Aug 27].Nat Immunol. 2020;10.1038/s41590-020-0779-1. doi:1038/s41590-020-0779-1
  23. Zeng Z, Yu H, Chen H, et al. Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China.Crit Care. 2020;24(1):525. Published 2020 Aug 27. doi:1186/s13054-020-03255-0
  24. Ueland T, Heggelund L, Lind A, Holten AR, Tonby K, Michelsen AE, Jenum S, Jørgensen MJ, Barratt-Due A, Skeie LG, Nordøy I, Aanensen Fraz MS, Quist-Paulsen E E, Pischke SE, Johal SK, Hesstvedt L, Bogen M, Fevang B, Halvorsen B, Müller F, Bekken GK, Mollnes TE, Dudman S, Aukrust P, Dyrhol-Riise AM, Holter JC. Elevated plasma sTIM-3 levels in severe Covid-19 patients. J Allergy Clin Immunol. 2020 Sep 21:S0091-6749(20)31314-2. doi: 10.1016/j.jaci.2020.09.007. Epub ahead of print. PMID: 32971109.
  25. Satış H, Özger HS, Aysert Yıldız P, Hızel K, Gulbahar Ö, Erbaş G, Aygencel G, Guzel Tunccan O, Öztürk MA, Dizbay M, Tufan A. Prognostic value of interleukin-18 and its association with other inflammatory markers and disease severity in COVID-19. Cytokine. 2020 Sep 28;137:155302. doi: 10.1016/j.cyto.2020.155302. Epub ahead of print. PMID: 33002740; PMCID: PMC7522034.
  26. Tang Y, Li Y, Sun J, Pan H, Yao F, Jiao X. Selection of an Optimal Combination Panel to Better Triage COVID-19 Hospitalized Patients. J Inflamm Res. 2020 Oct 27;13:773-787. doi: 10.2147/JIR.S273193. PMID: 33149652; PMCID: PMC7602889.
  27. Fomina DS, Lysenko MA, Beloglazova IP, Mutovina ZY, Poteshkina NG, Samsonova IV, Kruglova TS, Chernov AA, Karaulov AV. Temporal Clinical and Laboratory Response to Interleukin-6 Receptor Blockade With Tocilizumab in 89 Hospitalized Patients With COVID-19 Pneumonia. Pathog Immun. 2020 Oct 2;5(1):327-341. doi: 10.20411/pai.v5i1.392. PMID: 33089038; PMCID: PMC7556411.
  28. Hariharan A, Hakeem AR, Radhakrishnan S, Reddy MS, Rela M. The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients. Inflammopharmacology. 2020 Nov 7. doi: 10.1007/s10787-020-00773-9. Epub ahead of print. PMID: 33159646.
  29. Vashistha P, Gupta A, Arya M, Kumar Singh V, Dubey A, Chandra Koner B. Biclonal gammopathay in a case of severe COVID-19. Clin Chim Acta. 2020 Nov 4:S0009-8981(20)30523-4. doi: 10.1016/j.cca.2020.10.040. Epub ahead of print. PMID: 33159954.
  30. Angioni R, Sánchez-Rodríguez R, Munari F, Bertoldi N, Arcidiacono D, Cavinato S, Marturano D, Zaramella A, Realdon S, Cattelan A, Viola A, Molon B. Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients. Cell Death Dis. 2020 Nov 6;11(11):957. doi: 10.1038/s41419-020-03151-z. PMID: 33159040.
  31. Ji P, Zhu J, Zhong Z, Li H, Pang J, Li B, Zhang J. Association of elevated inflammatory markers and severe COVID-19: A meta-analysis. Medicine (Baltimore). 2020 Nov 20;99(47):e23315. doi: 10.1097/MD.0000000000023315. PMID: 33217868; PMCID: PMC7676531.
  32. Druyan A, Lidar M, Brodavka M, Levy I, Barzilai A, Pavlotsky F. The risk for severe COVID 19 in patients with autoimmune and/or inflammatory diseases: First wave lessons. Dermatol Ther. 2020 Dec 5. doi: 10.1111/dth.14627. Epub ahead of print. PMID: 33277764.
  33. Bülow Anderberg S, Luther T, Berglund M, Larsson R, Rubertsson S, Lipcsey M, Larsson A, Frithiof R, Hultström M. Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients. Cytokine. 2020 Dec 14;138:155389. doi: 10.1016/j.cyto.2020.155389. Epub ahead of print. PMID: 33348065.
  34. Salama C, Han J, Yau L, Reiss WG, Kramer B, Neidhart JD, Criner GJ, Kaplan-Lewis E, Baden R, Pandit L, Cameron ML, Garcia-Diaz J, Chávez V, Mekebeb-Reuter M, Lima de Menezes F, Shah R, González-Lara MF, Assman B, Freedman J, Mohan SV. Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia. N Engl J Med. 2021 Jan 7;384(1):20-30. doi: 10.1056/NEJMoa2030340. Epub 2020 Dec 17. PMID: 33332779; PMCID: PMC7781101.
  35. Lorenz G, Moog P, Bachmann Q, La Rosée P, Schneider H, Schlegl M, Spinner C, Heemann U, Schmid RM, Algül H, Lahmer T, Huber W, Schmaderer C. Title: Cytokine release syndrome is not usually caused by secondary hemophagocytic lymphohistiocytosis in a cohort of 19 critically ill COVID-19 patients. Sci Rep. 2020 Oct 26;10(1):18277. doi: 10.1038/s41598-020-75260-w. PMID: 33106497; PMCID: PMC7589537.
  36. Chen LYC, Hoiland RL, Stukas S, Wellington CL, Sekhon MS. Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome. Eur Respir J. 2020 Oct 1;56(4):2003006. doi: 10.1183/13993003.03006-2020. PMID: 32883678; PMCID: PMC7474149.
  37. Chen LYC, Hoiland RL, Stukas S, Wellington CL, Sekhon MS. Assessing the importance of interleukin-6 in COVID-19. Lancet Respir Med. 2021 Jan 15:S2213-2600(20)30600-7. doi: 10.1016/S2213-2600(20)30600-7. Epub ahead of print. PMID: 33460569; PMCID: PMC7836242.

 

 

 

 

 

Cardiac Markers:

  1. Lippi G, Lavie CJ, Sanchis-Gomar F. Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): Evidence from a meta-analysis. Progress in cardiovascular diseases. 2020 Mar 10. PMID:32169400
  2. Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, Wang H, Wan J, Wang X, Lu Z. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA cardiology. 2020 Mar 27. PMID: 32219356
  3. Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nature Reviews Cardiology. 2020 Mar 5:1-2. PMID:32139904
  4. American College of Cardiology. Troponin and BNP Use in COVID-19. 28 Mar 2020.
  5. Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, Gong W, Liu X, Liang J, Zhao Q, Huang H. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA cardiology. 2020 Mar 25. PMID: 32211816
  6. Chapman AR, Bularga A, Mills NL. High-Sensitivity Cardiac Troponin Can Be An Ally in the Fight Against COVID-19. Circulation. 2020 Apr 6. PMID: 32251612
  7. Shi S, Qin M, Cai Y, Liu T, Shen B, Yang F, Cao S, Liu X, Xiang Y, Zhao Q, Huang H. Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019. European Heart Journal. 2020 May 11. PMID: 32391877
  8. Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood, The Journal of the American Society of Hematology. 2020 Jun 4;135(23):2033-40. PMID: 32339221
  9. Harmouch F, Shah K, Hippen J, Kumar A, Goel H. Is it all in the heart? Myocardial injury as major predictor of mortality among hospitalized COVID-19 patients [published online ahead of print, 2020 Jul 25]. J Med Virol. 2020;10.1002/jmv.26347. doi:10.1002/jmv.26347
  10. Deng P, Ke Z, Ying B, Qiao B, Yuan L. The diagnostic and prognostic role of myocardial injury biomarkers in hospitalized patients with COVID-19 [published online ahead of print, 2020 Jul 16]. Clin Chim Acta. 2020;510:186-190. doi:10.1016/j.cca.2020.07.018
  11. Qin JJ, Cheng X, Zhou F, et al. Redefining cardiac biomarkers in predicting mortality of inpatients with COVID-19 [published online ahead of print, 2020 Jul 14]. Hypertension. 2020;10.1161/HYPERTENSIONAHA.120.15528. doi:10.1161/HYPERTENSIONAHA.120.15528
  12. Hafiane A. SARS-CoV-2 and the cardiovascular system [published online ahead of print, 2020 Jul 16]. Clin Chim Acta. 2020;510:311-316. doi:10.1016/j.cca.2020.07.019
  13. Deng P, Ke Z, Ying B, Qiao B, Yuan L. The diagnostic and prognostic role of myocardial injury biomarkers in hospitalized patients with COVID-19 [published online ahead of print, 2020 Jul 16]. Clin Chim Acta. 2020;510:186-190. doi:10.1016/j.cca.2020.07.018
  14. Sawalha K, Abozenah M, Kadado AJ, et al. Systematic review of COVID-19 related myocarditis: Insights on management and outcome [published online ahead of print, 2020 Aug 18].Cardiovasc Revasc Med. 2020;S1553-8389(20)30497-8. doi:10.1016/j.carrev.2020.08.028
  15. Lombardi CM, Carubelli V, Iorio A, et al. Association of Troponin Levels With Mortality in Italian Patients Hospitalized With Coronavirus Disease 2019: Results of a Multicenter Study [published online ahead of print, 2020 Aug 26].JAMA Cardiol. 2020;10.1001/jamacardio.2020.3538. doi:10.1001/jamacardio.2020.3538
  16. Liu D, Yang Q, Chen W, et al. Troponin I, a risk factor indicating more severe pneumonia among patients with novel coronavirus infected pneumonia.Clin Infect Pract. 2020;7:100037. doi:10.1016/j.clinpr.2020.100037
  17. Raad M, Dabbagh M, Gorgis S, et al. Cardiac Injury Patterns and Inpatient Outcomes Among Patients Admitted With COVID-19 [published online ahead of print, 2020 Jul 24].Am J Cardiol. 2020;S0002-9149(20)30774-8. doi:10.1016/j.amjcard.2020.07.040
  18. Stefanini GG, Chiarito M, Ferrante G, et al. Early detection of elevated cardiac biomarkers to optimise risk stratification in patients with COVID-19 [published online ahead of print, 2020 Aug 14].Heart. 2020;heartjnl-2020-317322. doi:10.1136/heartjnl-2020-317322
  19. Shah P, Doshi R, Chenna A, et al. Prognostic Value of Elevated Cardiac Troponin I in Hospitalized Covid-19 Patients [published online ahead of print, 2020 Aug 27]. Am J Cardiol. 2020;S0002-9149(20)30898-5. doi:10.1016/j.amjcard.2020.08.041
  20. Aladağ N, Atabey RD. The role of concomitant cardiovascular diseases and cardiac biomarkers for predicting mortality in critical COVID-19 patients [published online ahead of print, 2020 Sep 4]. Acta Cardiol. 2020;1-8. doi:10.1080/00015385.2020.1810914
  21. Wu AHB, Zhang Y, Webber R. Extracellular vesicles released in blood of COVID-19 patients: mechanism for detection of cardiac troponin after myocardial injury? Biomarkers. 2020 Sep 25:1-10. doi: 10.1080/1354750X.2020.1829055. Epub ahead of print. PMID: 32977728.
  22. Bojkova D, Wagner JUG, Shumliakivska M, Aslan GS, Saleem U, Hansen A, Luxán G, Günther S, Pham MD, Krishnan J, Harter PN, Ermel UH, Frangakis AS, Milting H, Zeiher AM, Klingel K, Cinatl J, Dendorfer A, Eschenhagen T, Tschöpe C, Ciesek S, Dimmeler S. SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes. Cardiovasc Res. 2020 Sep 23:cvaa267. doi: 10.1093/cvr/cvaa267. Epub ahead of print. PMID: 32966582.
  23. Zhou W, Song L, Wang X, Xu Z, Wang S, Wang J, Xu H, Zheng Y, Wang Y. Cardiac injury prediction and lymphocyte immunity and inflammation analysis in hospitalized patients with coronavirus disease 2019 (COVID-19). Int J Cardiol. 2020 Oct 21:S0167-5273(20)34002-X. doi: 10.1016/j.ijcard.2020.10.049. Epub ahead of print. PMID: 33098952.
  24. Severino P, D'Amato A, Saglietto A, D'Ascenzo F, Marini C, Schiavone M, Ghionzoli N, Pirrotta F, Troiano F, Cannillo M, Mennuni M, Rognoni A, Rametta F, Galluzzo A, Agnes G, Infusino F, Pucci M, Lavalle C, Cacciotti L, Mather PJ, Grosso Marra W, Ugo F, Forleo G, Viecca M, Morici N, Patti G, De Ferrari GM, Palazzuoli A, Mancone M, Fedele F. Reduction in heart failure hospitalization rate during coronavirus disease 19 pandemic outbreak. ESC Heart Fail. 2020 Oct 23. doi: 10.1002/ehf2.13043. Epub ahead of print. PMID: 33094929.
  25. Baldi E, Sechi GM, Mare C, Canevari F, Brancaglione A, Primi R, Palo A, Contri E, Ronchi V, Beretta G, Reali F, Parogni PP, Facchin F, Rizzi U, Bussi D, Ruggeri S, Oltrona Visconti L, Savastano S; all the Lombardia CARe researchers. Treatment of out-of-hospital cardiac arrest in the COVID-19 era: A 100 days experience from the Lombardy region. PLoS One. 2020 Oct 22;15(10):e0241028. doi: 10.1371/journal.pone.0241028. PMID: 33091034.
  26. Piccioni A, Brigida M, Loria V, Zanza C, Longhitano Y, Zaccaria R, Racco S, Gasbarrini A, Ojetti V, Franceschi F, Candelli M. Role of troponin in COVID-19 pandemic: a review of literature. Eur Rev Med Pharmacol Sci. 2020 Oct;24(19):10293-10300. doi: 10.26355/eurrev_202010_23254. PMID: 33090441.
  27. Kavsak PA, Mondoux SE, de Wit K, Rochwerg B, Main C, Yamamura D, Paré G, Ma J, Perri D, Sherbino J, Worster A. Admission high-sensitivity cardiac troponin versus a biochemical score for predicting mortality in patients with COVID-19. CJC Open. 2020 Oct 14. doi: 10.1016/j.cjco.2020.10.008. Epub ahead of print. PMID: 33073223; PMCID: PMC7553859.
  28. Kavsak PA, Hammarsten O, Worster A, Smith SW, Apple FS. Cardiac Troponin Testing in Patients with COVID-19: A Strategy for Testing and Reporting Results. Clin Chem. 2020 Oct 12:hvaa225. doi: 10.1093/clinchem/hvaa225. Epub ahead of print. PMID: 33045044.
  29. Giustino G, Croft LB, Stefanini GG, Bragato R, Silbiger JJ, Vicenzi M, Danilov T, Kukar N, Shaban N, Kini A, Camaj A, Bienstock SW, Rashed ER, Rahman K, Oates CP, Buckley S, Elbaum LS, Arkonac D, Fiter R, Singh R, Li E, Razuk V, Robinson SE, Miller M, Bier B, Donghi V, Pisaniello M, Mantovani R, Pinto G, Rota I, Baggio S, Chiarito M, Fazzari F, Cusmano I, Curzi M, Ro R, Malick W, Kamran M, Kohli-Seth R, Bassily-Marcus AM, Neibart E, Serrao G, Perk G, Mancini D, Reddy VY, Pinney SP, Dangas G, Blasi F, Sharma SK, Mehran R, Condorelli G, Stone GW, Fuster V, Lerakis S, Goldman ME. Characterization of Myocardial Injury in Patients With COVID-19. J Am Coll Cardiol. 2020 Nov 3;76(18):2043-2055. doi: 10.1016/j.jacc.2020.08.069. PMID: 33121710; PMCID: PMC7588179.
  30. Manocha KK, Kirzner J, Ying X, Yeo I, Peltzer B, Ang B, Li HA, Lerman BB, Safford MM, Goyal P, Cheung JW. Troponin and Other Biomarker Levels and Outcomes Among Patients Hospitalized with COVID-19: Derivation and Validation of the HA2T2COVID-19 Mortality Risk Score. J Am Heart Assoc. 2020 Oct 30:e018477. doi: 10.1161/JAHA.120.018477. Epub ahead of print. PMID: 33121304.
  31. Gregory AT, Pepe S, Denniss AR. COVID-19 and Heart, Lung and Circulation: Riding the 2020 Waves of Change in Australia & New Zealand✰. Heart Lung Circ. 2020 Dec;29(12):1737-1740. doi: 10.1016/j.hlc.2020.10.008. PMID: 33218388.
  32. Mustroph J, Hupf J, Hanses F, Evert K, Baier MJ, Evert M, Meindl C, Wagner S, Hubauer U, Pietrzyk G, Leininger S, Staudner S, Vogel M, Wallner S, Zimmermann M, Sossalla S, Maier LS, Jungbauer C. Decreased GLUT1/NHE1 RNA expression in whole blood predicts disease severity in patients with COVID-19. ESC Heart Fail. 2020 Nov 20. doi: 10.1002/ehf2.13063. Epub ahead of print. PMID: 33215884.
  33. Butt JH, Gerds TA, Schou M, Kragholm K, Phelps M, Havers-Borgersen E, Yafasova A, Gislason GH, Torp-Pedersen C, Køber L, Fosbøl EL. Association between statin use and outcomes in patients with coronavirus disease 2019 (COVID-19): a nationwide cohort study. BMJ Open. 2020 Dec 4;10(12):e044421. doi: 10.1136/bmjopen-2020-044421. PMID: 33277291.
  34. Agarwal MA, Ziaeian B, Lavie CJ, Fonarow GC. Cardiovascular Disease in Hospitalized Patients With a Diagnosis of Coronavirus From the Pre-COVID-19 Era in United States: National Analysis From 2016-2017. Mayo Clin Proc. 2020 Dec;95(12):2674-2683. doi: 10.1016/j.mayocp.2020.09.022. Epub 2020 Sep 22. PMID: 33276839.
  35. Case BC, Yerasi C, Forrestal BJ, Shea C, Rappaport H, Medranda GA, Zhang C, Satler LF, Ben-Dor I, Hashim H, Rogers T, Waksman R. Comparison of Characteristics and Outcomes of Patients with Acute Myocardial Infarction with versus without Coronarvirus-19. Am J Cardiol. 2020 Dec 29:S0002-9149(20)31410-7. doi: 10.1016/j.amjcard.2020.12.059. Epub ahead of print. PMID: 33385357; PMCID: PMC7771301.
  36. Liu Z, Li J, Li M, Chen S, Gao R, Zeng G, Chen D, Wang S, Li Q, Hu D, Zeng W, Guo L, Wu X. Elevated α-hydroxybutyrate dehydrogenase as an independent prognostic factor for mortality in hospitalized patients with COVID-19. ESC Heart Fail. 2020 Dec 17. doi: 10.1002/ehf2.13151. Epub ahead of print. PMID: 33336560.
  37. Ranasinghe RNK, Taylor DR, Mazaheri T, Al-Hasani W, Buchanan D, Rao N, Vincent RP. Cardiac markers in Black, Asian and minority ethnic (BAME) patients with COVID-19. J Clin Pathol. 2020 Dec 10:jclinpath-2020-207188. doi: 10.1136/jclinpath-2020-207188. Epub ahead of print. PMID: 33303528.
  38. Page EM, Ariëns RAS. Mechanisms of thrombosis and cardiovascular complications in COVID-19. Thromb Res. 2021 Jan 18;200:1-8. doi: 10.1016/j.thromres.2021.01.005. Epub ahead of print. PMID: 33493983; PMCID: PMC7813504.
  39. Shi X, Chen M, Zhang Y. The cardiovascular disorders and prognostic cardiac biomarkers in COVID-19. Mol Biol Rep. 2021 Jan 22:1–9. doi: 10.1007/s11033-021-06148-9. Epub ahead of print. PMID: 33483864; PMCID: PMC7822398.
  40. Belarte-Tornero LC, Valdivielso-Moré S, Vicente Elcano M, Solé-González E, Ruíz-Bustillo S, Calvo-Fernández A, Subinara I, Cabero P, Soler C, Cubero-Gallego H, Vaquerizo B, Farré N. Prognostic Implications of Chronic Heart Failure and Utility of NT-proBNP Levels in Heart Failure Patients with SARS-CoV-2 Infection. J Clin Med. 2021 Jan 17;10(2):323. doi: 10.3390/jcm10020323. PMID: 33477268; PMCID: PMC7829899.

 

 

 

 

 

Hematology Markers:

  1. Fan BE, Chong VC, Chan SS, Lim GH, Lim KG, Tan GB, Mucheli SS, Kuperan P, Ong KH. Hematologic parameters in patients with COVID-19 infection. American journal of hematology. 2020 Mar 4. PMID:32129508
  2. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clinica Chimica Acta. 2020 Mar 13. PMID:32178975
  3. Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Journal of Thrombosis and Haemostasis. 2020 Jan 1. PMID:32073213
  4. Han H, Yang L, Liu R, Liu F, Wu KL, Li J, Liu XH, Zhu CL. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clinical Chemistry and Laboratory Medicine (CCLM). 2020 Mar 16;1(ahead-of-print). PMID: 32172226
  5. Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, Chen H, Ding X, Zhao H, Zhang H, Wang C. Coagulopathy and antiphospholipid antibodies in patients with Covid-19. New England Journal of Medicine. 2020 Apr 8. PMID: 32268022
  6. Salamanna F, Maglio M, Landini MP, Fini M. Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (Covid-19). Platelets. 2020 May 12:1-6. PMID: 32397915
  7. Levi M, Thachil J, Iba T, Levy JH. Coagulation abnormalities and thrombosis in patients with COVID-19. The Lancet Haematology. 2020 May 11. PMID: 32407672
  8. Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JC, Fogerty AE, Waheed A, Goodarzi K, Bendapudi P, Bornikova L, Gupta S, Leaf D, Kuter DJ, Rosovsky RP. COVID and Coagulation: Bleeding and Thrombotic Manifestations of SARS-CoV2 Infection. Blood. 2020 Jun 3:blood.2020006520. doi: 10.1182/blood.2020006520. Epub ahead of print. PMID: 32492712.
  9. Dewaele K, Claeys R. Hemophagocytic lymphohistiocytosis in SARS-CoV-2 infection. Blood. 2020 Jun 18;135(25):2323. doi: 10.1182/blood.2020006505. PMID: 32556137.
  10. Mezalek ZT, Khibri H, Ammouri W, et al. COVID-19 Associated Coagulopathy and Thrombotic Complications. Clin Appl Thromb Hemost. 2020;26:1076029620948137. doi:10.1177/1076029620948137
  11. Hardy M, Douxfils J, Bareille M, et al. Studies on hemostasis in COVID-19 deserve careful reporting of the laboratory methods, their significance and their limitations [published online ahead of print, 2020 Aug 13]. J Thromb Haemost. 2020;10.1111/jth.15061. doi:10.1111/jth.15061
  12. Nicolai L, Leunig A, Brambs S, et al. Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy [published online ahead of print, 2020 Jul 28]. Circulation. 2020;10.1161/CIRCULATIONAHA.120.048488. doi:10.1161/CIRCULATIONAHA.120.048488
  13. Elshazli RM, Toraih EA, Elgaml A, et al. Diagnostic and prognostic value of hematological and immunological markers in COVID-19 infection: A meta-analysis of 6320 patients.PLoS One. 2020;15(8):e0238160. Published 2020 Aug 21. doi:10.1371/journal.pone.0238160
  14. Zhang S, Liu Y, Wang X, et al. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. J Hematol Oncol. 2020;13(1):120. Published 2020 Sep 4. doi:10.1186/s13045-020-00954-7
  15. Christensen B, Favaloro EJ, Lippi G, Van Cott EM. Hematology Laboratory Abnormalities in Patients with Coronavirus Disease 2019 (COVID-19) [published online ahead of print, 2020 Sep 2]. Semin Thromb Hemost. 2020;10.1055/s-0040-1715458. doi:10.1055/s-0040-1715458
  16. Kasal DA, De Lorenzo A, Tibiriçá E. COVID-19 and Microvascular Disease: Pathophysiology of SARS-CoV-2 Infection With Focus on the Renin-Angiotensin System. Heart Lung Circ. 2020 Sep 2:S1443-9506(20)30443-1. doi: 10.1016/j.hlc.2020.08.010. Epub ahead of print. PMID: 32972810.
  17. Ferrari E, Sartre B, Squara F, Contenti J, Occelli C, Lemoel F, Levraut J, Doyen D, Dellamonica J, Mondain V, Chirio D, Risso K, Cua E, Orban JC, Ichai C, Labbaoui M, Mossaz B, Moceri P, Appert-Flory A, Fischer F, Toulon P. High prevalence of acquired thrombophilia without prognosis value in Covid-19 patients. J Am Heart Assoc. 2020 Sep 25:e017773. doi: 10.1161/JAHA.120.017773. Epub ahead of print. PMID: 32972320.
  18. Schulman S, Hu Y, Konstantinides S. Venous Thromboembolism in COVID-19. Thromb Haemost. 2020 Oct 24. doi: 10.1055/s-0040-1718532. Epub ahead of print. PMID: 33099284.
  19. Fan BE, Ng J, Chan SSW, Christopher D, Tso ACY, Ling LM, Young BE, Wong LJL, Sum CLL, Tan HT, Ang MK, Lim GH, Ong KH, Kuperan P, Chia YW. COVID-19 associated coagulopathy in critically ill patients: A hypercoagulable state demonstrated by parameters of haemostasis and clot waveform analysis. J Thromb Thrombolysis. 2020 Oct 24. doi: 10.1007/s11239-020-02318-x. Epub ahead of print. PMID: 33098540.
  20. Bourguignon A, Beaulieu C, Belkaid W, Desilets A, Blais N. Incidence of thrombotic outcomes for patients hospitalized and discharged after COVID-19 infection. Thromb Res. 2020 Oct 15;196:491-493. doi: 10.1016/j.thromres.2020.10.017. Epub ahead of print. PMID: 33091702; PMCID: PMC7557256.
  21. Daughety MM, Morgan A, Frost E, Kao C, Hwang J, Tobin R, Patel B, Fuller M, Welsby I, Ortel TL. COVID-19 associated coagulopathy: Thrombosis, hemorrhage and mortality rates with an escalated-dose thromboprophylaxis strategy. Thromb Res. 2020 Oct 15;196:483-485. doi: 10.1016/j.thromres.2020.10.004. Epub ahead of print. PMID: 33091700; PMCID: PMC7557260.
  22. Anurag A, Jha PK, Kumar A. Differential white blood cell count in the COVID-19: A cross-sectional study of 148 patients. Diabetes Metab Syndr. 2020 Nov 2;14(6):2099-2102. doi: 10.1016/j.dsx.2020.10.029. Epub ahead of print. PMID: 33160224.
  23. Fan BE, Umapathi T, Chua K, Chia YW, Wong SW, Tan GWL, Chandrasekar S, Lum YH, Vasoo S, Dalan R. Delayed catastrophic thrombotic events in young and asymptomatic post COVID-19 patients. J Thromb Thrombolysis. 2020 Nov 7. doi: 10.1007/s11239-020-02332-z. Epub ahead of print. PMID: 33159640.
  24. Mui LW, Lau JF, Lee HK. Thromboembolic complications of COVID-19. Emerg Radiol. 2020 Nov 7. doi: 10.1007/s10140-020-01868-0. Epub ahead of print. PMID: 33159219.
  25. Fan BE, Umapathi T, Chua K, Chia YW, Wong SW, Tan GWL, Chandrasekar S, Lum YH, Vasoo S, Dalan R. Delayed catastrophic thrombotic events in young and asymptomatic post COVID-19 patients. J Thromb Thrombolysis. 2020 Nov 7:1–7. doi: 10.1007/s11239-020-02332-z. Epub ahead of print. PMID: 33159640; PMCID: PMC7648538.
  26. Tsantes AE, Frantzeskaki F, Tsantes AG, Rapti E, Rizos M, Kokoris SI, Paramythiotou E, Katsadiotis G, Karali V, Flevari A, Chrysanthopoulou E, Maratou E, Kyriakou E, Gialeraki A, Bonovas S, Dimopoulos G, Tsangaris I, Armaganidis A. The haemostatic profile in critically ill COVID-19 patients receiving therapeutic anticoagulant therapy: An observational study. Medicine (Baltimore). 2020 Nov 20;99(47):e23365. doi: 10.1097/MD.0000000000023365. PMID: 33217881; PMCID: PMC7676559.
  27. Lv Y, Chen L, Liang X, Liu X, Gao M, Wang Q, Wei Q, Liu L. Association between iron status and the risk of adverse outcomes in COVID-19. Clin Nutr. 2020 Dec 9:S0261-5614(20)30654-3. doi: 10.1016/j.clnu.2020.11.033. Epub ahead of print. PMID: 33380357; PMCID: PMC7723754.
  28. van der Linden J, Almskog L, Liliequist A, Grip J, Fux T, Rysz S, Ågren A, Oldner A, Ståhlberg M. Thromboembolism, Hypercoagulopathy, and Antiphospholipid Antibodies in Critically Ill Coronavirus Disease 2019 Patients: A Before and After Study of Enhanced Anticoagulation. Crit Care Explor. 2020 Dec 17;2(12):e0308. doi: 10.1097/CCE.0000000000000308. PMID: 33364605; PMCID: PMC7752689.
  29. Trimaille A, Thachil J, Marchandot B, Curtiaud A, Leonard-Lorant I, Carmona A, Matsushita K, Sato C, Sattler L, Grunebaum L, Hansmann Y, Fafi-Kremer S, Jesel L, Ohana M, Morel O. D-Dimers Level as a Possible Marker of Extravascular Fibrinolysis in COVID-19 Patients. J Clin Med. 2020 Dec 24;10(1):E39. doi: 10.3390/jcm10010039. PMID: 33374487.
  30. Ruberto F, Chistolini A, Curreli M, Frati G, Marullo AGM, Biondi-Zoccai G, Mancone M, Sciarretta S, Miraldi F, Alessandri F, Ceccarelli G, Barone F, Santoro C, Alvaro D, Pugliese F, Pulcinelli FM; Policlinico Umberto I COVID-19 Group. Von Willebrand factor with increased binding capacity is associated with reduced platelet aggregation but enhanced agglutination in COVID-19 patients: another COVID-19 paradox? J Thromb Thrombolysis. 2021 Jan 2. doi: 10.1007/s11239-020-02339-6. Epub ahead of print. PMID: 33387210.
  31. Lanini S, Montaldo C, Nicastri E, Vairo F, Agrati C, Petrosillo N, Scognamiglio P, Antinori A, Puro V, Di Caro A, De Carli G, Navarra A, Agresta A, Cimaglia C, Palmieri F, D'Offizi G, Marchioni L, Kobinger GP, Maeurer M, Girardi E, Capobianchi MR, Zumla A, Locatelli F, Ippolito G. COVID-19 disease-Temporal analyses of complete blood count parameters over course of illness, and relationship to patient demographics and management outcomes in survivors and non-survivors: A longitudinal descriptive cohort study. PLoS One. 2020 Dec 28;15(12):e0244129. doi: 10.1371/journal.pone.0244129. PMID: 33370366.
  32. Lombardi A, Trombetta E, Cattaneo A, Castelli V, Palomba E, Tirone M, Mangioni D, Lamorte G, Manunta M, Prati D, Ceriotti F, Gualtierotti R, Costantino G, Aliberti S, Scaravilli V, Grasselli G, Gori A, Porretti L, Bandera A. Early Phases of COVID-19 Are Characterized by a Reduction in Lymphocyte Populations and the Presence of Atypical Monocytes. Front Immunol. 2020 Dec 9;11:560330. doi: 10.3389/fimmu.2020.560330. PMID: 33362757; PMCID: PMC7756112.
  33. Di Micco P, Russo V, Carannante N, Imparato M, Cardillo G, Lodigiani C. Prognostic Value of Fibrinogen among COVID-19 Patients Admitted to an Emergency Department: An Italian Cohort Study. J Clin Med. 2020 Dec 21;9(12):4134. doi: 10.3390/jcm9124134. PMID: 33371524; PMCID: PMC7767519.

 

 

 

 

 

Hepatic & Renal Markers:

  1. Bangash MN, Patel J, Parekh D. COVID-19 and the liver: little cause for concern. The Lancet Gastroenterology & Hepatology. 2020 Mar 20. PMID: 32203680
  2. Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, Li J, Yao Y, Ge S, Xu G. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney international. 2020 Mar 20. PMID: 32247631
  3. Fan Z, Chen L, Li J, Cheng X, Yang J, Tian C, Zhang Y, Huang S, Liu Z, Cheng J. Clinical features of COVID-19-related liver damage. Clinical Gastroenterology and Hepatology. 2020 Apr 10. PMID: 32283325
  4. Lax SF, Skok K, Zechner P, Kessler HH, Kaufmann N, Koelblinger C, Vander K, Bargfrieder U, Trauner M. Pulmonary arterial thrombosis in COVID-19 with fatal outcome: results from a prospective, single-center, clinicopathologic case series. Annals of Internal Medicine. 2020 May. PMID: 32422076
  5. Agarwal A, Chen A, Ravindran N, To C, Thuluvath PJ. Gastrointestinal and liver manifestations of COVID-19. Journal of Clinical and Experimental Hepatology. 2020 Apr 1. PMCID: PMC7212283
  6. Su H, Yang M, Wan C, Yi LX, Tang F, Zhu HY, Yi F, Yang HC, Fogo AB, Nie X, Zhang C. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney international. 2020 Apr 9. PMID: 32327202
  7. Portincasa P, Krawczyk M, Smyk W, Lammert F, Di Ciaula A. COVID-19 and nonalcoholic fatty liver disease: two intersecting pandemics [published online ahead of print, 2020 Jun 26]. Eur J Clin Invest. 2020;e13338. doi:10.1111/eci.13338
  8. Sun JK, Zhang WH, Zou L, et al. Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019 [published online ahead of print, 2020 Jun 25]. Aging (Albany NY). 2020;12:10.18632/aging.103526. doi:10.18632/aging.103526
  9. Bertolini A, van de Peppel IP, Bodewes FAJA, et al. Abnormal liver function tests in COVID-19 patients: relevance and potential pathogenesis [published online ahead of print, 2020 Jul 23]. Hepatology. 2020;10.1002/hep.31480. doi:10.1002/hep.31480
  10. Zarifian A, Bidary MZ, Arekhi S, et al. Gastrointestinal and hepatic abnormalities in patients with confirmed COVID-19: a systematic review and meta-analysis [published online ahead of print, 2020 Jul 18]. J Med Virol. 2020;10.1002/jmv.26314. doi:10.1002/jmv.26314
  11. Saad Alharbi K, Al-Abbasi FA, Prasad Agrawal G, Sharma A, Kowti R, Kazmi I. Impact of COVID-19 on Nephrology Patients: A Mechanistic Outlook for Pathogenesis of Acute Kidney Injury [published online ahead of print, 2020 Jul 15]. Altern Ther Health Med. 2020;AT6544.
  12. Boregowda U, Aloysius MM, Perisetti A, Gajendran M, Bansal P, Goyal H. Serum Activity of Liver Enzymes Is Associated With Higher Mortality in COVID-19: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 2020;7:431. Published 2020 Jul 22. doi:10.3389/fmed.2020.00431
  13. Scarpellini E, Fagoonee S, Rinninella E, et al. Gut Microbiota and Liver Interaction through Immune System Cross-Talk: A Comprehensive Review at the Time of the SARS-CoV-2 Pandemic. J Clin Med. 2020;9(8):E2488. Published 2020 Aug 3. doi:10.3390/jcm9082488
  14. Ramachandran P, Perisetti A, Gajendran M, Chakraborti A, Narh JT, Goyal H. Increased Serum Aminotransferase Activity and Clinical Outcomes in Coronavirus Disease 2019 [published online ahead of print, 2020 Jun 30].J Clin Exp Hepatol. 2020;10.1016/j.jceh.2020.06.009. doi:10.1016/j.jceh.2020.06.009
  15. El Ouali S, Romero-Marrero C, Regueiro M. Hepatic manifestations of COVID-19 [published online ahead of print, 2020 Aug 27].Cleve Clin J Med. 2020;10.3949/ccjm.87a.ccc061. doi:10.3949/ccjm.87a.ccc061
  16. Ghoshal UC, Ghoshal U, Dhiman RK. Gastrointestinal and Hepatic Involvement in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Review [published online ahead of print, 2020 Jun 11].J Clin Exp Hepatol. 2020;10.1016/j.jceh.2020.06.002. doi:10.1016/j.jceh.2020.06.002
  17. Gao Y, Li Q, Shi H, et al. Preliminary Exploration of the Cause of Liver Disorders During Early Stages in COVID-19 Patients. Front Med (Lausanne). 2020;7:501. Published 2020 Aug 7. doi:10.3389/fmed.2020.00501
  18. Bernal-Monterde V, Casas-Deza D, Letona-Giménez L, et al. SARS-CoV-2 Infection Induces a Dual Response in Liver Function Tests: Association with Mortality during Hospitalization. Biomedicines. 2020;8(9):E328. Published 2020 Sep 4. doi:10.3390/biomedicines8090328
  19. Kovalic AJ, Huang G, Thuluvath PJ, Satapathy SK. Reply to Letter to the Editor: Elevated Liver Biochemistries in Hospitalized Chinese Patients With Severe COVID-19: Systematic Review and Meta-Analysis [published online ahead of print, 2020 Sep 7]. Hepatology. 2020;10.1002/hep.31542. doi:10.1002/hep.31542
  20. Tsibouris P, Ekmektzoglou K, Agorogianni A, et al. Gastrointestinal involvement in COVID-19 patients: a retrospective study from a Greek COVID-19 referral hospital. Ann Gastroenterol. 2020;33(5):465-472. doi:10.20524/aog.2020.0514
  21. Zhou YH, Zheng KI, Targher G, Byrne CD, Zheng MH. Abnormal liver enzymes in children and infants with COVID-19: A narrative review of case-series studies [published online ahead of print, 2020 Sep 1]. Pediatr Obes. 2020;e12723. doi:10.1111/ijpo.12723
  22. Mahamid M, Nseir W, Khoury T, et al. Nonalcoholic fatty liver disease is associated with COVID-19 severity independently of metabolic syndrome: a retrospective case-control study [published online ahead of print, 2020 Aug 28]. Eur J Gastroenterol Hepatol. 2020;10.1097/MEG.0000000000001902. doi:10.1097/MEG.0000000000001902
  23. Kullar R, Patel AP, Saab S. Hepatic Injury in Patients With COVID-19. J Clin Gastroenterol. 2020 Sep 23. doi: 10.1097/MCG.0000000000001432. Epub ahead of print. PMID: 32976196.
  24. Napodano C, Pocino K, Stefanile A, Marino M, Miele L, Gulli F, Basile V, Pandolfi F, Gasbarrini A, Rapaccini GL, Basile U. COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel. Scand J Immunol. 2020 Sep 15:e12977. doi: 10.1111/sji.12977. Epub ahead of print. PMID: 32931622.
  25. Ghoneim S, Butt MU, Hamid O, Shah A, Asaad I. The incidence of COVID-19 in patients with metabolic syndrome and non-alcoholic steatohepatitis: A population-based study. Metabol Open. 2020 Sep 9:100057. doi: 10.1016/j.metop.2020.100057. Epub ahead of print. PMID: 32924000; PMCID: PMC7480663.
  26. Cantaluppi V, Guglielmetti G, Dellepiane S, Marengo M, Mehta R, Ronco C. A call to action to evaluate renal functional reserve in COVID-19 patients. Am J Physiol Renal Physiol. 2020 Sep 24. doi: 10.1152/ajprenal.00245.2020. Epub ahead of print. PMID: 32969711.
  27. Siew ED, Birkelo BC. COVID-19-Associated Acute Kidney Injury: An Evolving Picture. Clin J Am Soc Nephrol. 2020 Sep 22:CJN.13600820. doi: 10.2215/CJN.13600820. Epub ahead of print. PMID: 32969342.
  28. COVID-19 rapid guideline: acute kidney injury in hospital. https://www.nice.org.uk/guidance/ng175
  29. Chan L, Chaudhary K, Saha A, Chauhan K, Vaid A, Zhao S, Paranjpe I, Somani S, Richter F, Miotto R, Lala A, Kia A, Timsina P, Li L, Freeman R, Chen R, Narula J, Just AC, Horowitz C, Fayad Z, Cordon-Cardo C, Schadt E, Levin MA, Reich DL, Fuster V, Murphy B, He JC, Charney AW, Böttinger EP, Glicksberg BS, Coca SG, Nadkarni GN; Mount Sinai COVID Informatics Center (MSCIC), Li L. AKI in Hospitalized Patients with COVID-19. J Am Soc Nephrol. 2020 Sep 3:ASN.2020050615. doi: 10.1681/ASN.2020050615. Epub ahead of print. PMID: 32883700.
  30. Hectors SJ, Riyahi S, Dev H, Krishnan K, Margolis DJA, Prince MR. Multivariate analysis of CT imaging, laboratory, and demographical features for prediction of acute kidney injury in COVID-19 patients: a Bi-centric analysis. Abdom Radiol (NY). 2020 Oct 24. doi: 10.1007/s00261-020-02823-w. Epub ahead of print. PMID: 33098478.
  31. Huh K, Lee R, Ji W, Kang M, Cheol Hwang I, Ho Lee D, Jung J. Impact of obesity, fasting plasma glucose level, blood pressure, and renal function on the severity of COVID-19: a matter of sexual dimorphism? Diabetes Res Clin Pract. 2020 Oct 20:108515. doi: 10.1016/j.diabres.2020.108515. Epub ahead of print. PMID: 33096185; PMCID: PMC7575440.
  32. Dennis JM, Mateen BA, Sonabend R, Thomas NJ, Patel KA, Hattersley AT, Denaxas S, McGovern AP, Vollmer SJ. Type 2 Diabetes and COVID-19-Related Mortality in the Critical Care Setting: A National Cohort Study in England, March-July 2020. Diabetes Care. 2020 Oct 23:dc201444. doi: 10.2337/dc20-1444. Epub ahead of print. PMID: 33097559.
  33. Hectors SJ, Riyahi S, Dev H, Krishnan K, Margolis DJA, Prince MR. Multivariate analysis of CT imaging, laboratory, and demographical features for prediction of acute kidney injury in COVID-19 patients: a Bi-centric analysis. Abdom Radiol (NY). 2020 Oct 24. doi: 10.1007/s00261-020-02823-w. Epub ahead of print. PMID: 33098478.
  34. Merola E, Pravadelli C, de Pretis G. Prevalence of liver injury in patients with coronavirus disease 2019 (COVID-19) : a systematic review and meta-analysis. Acta Gastroenterol Belg. 2020 Jul-Sep;83(3):454-460. PMID: 33094594.
  35. Fondevila MF, Mercado-Gómez M, Rodríguez A, Gonzalez-Rellan MJ, Iruzubieta P, Valentí V, Escalada J, Schwaninger M, Prevot V, Dieguez C, Crespo J, Frühbeck G, Martinez-Chantar ML, Nogueiras R. Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points. J Hepatol. 2020 Oct 5:S0168-8278(20)33671-0. doi: 10.1016/j.jhep.2020.09.027. Epub ahead of print. PMID: 33096086; PMCID: PMC7574841.
  36. Fu L, Fei J, Xu S, Xiang HX, Xiang Y, Hu B, Li MD, Liu FF, Li Y, Li XY, Zhao H, Xu DX. Liver Dysfunction and Its Association with the Risk of Death in COVID-19 Patients: A Prospective Cohort Study. J Clin Transl Hepatol. 2020 Sep 28;8(3):246-254. doi: 10.14218/JCTH.2020.00043. Epub 2020 Aug 20. PMID: 33083246; PMCID: PMC7562804.
  37. Sharma A, Jaiswal P, Kerakhan Y, Saravanan L, Murtaza Z, Zergham A, Honganur NS, Akbar A, Deol A, Francis B, Patel S, Mehta D, Jaiswal R, Singh J, Patel U, Malik P. Liver disease and outcomes among COVID-19 hospitalized patients- a systematic review and meta-analysis. Ann Hepatol. 2020 Oct 16:S1665-2681(20)30188-5. doi: 10.1016/j.aohep.2020.10.001. Epub ahead of print. PMID: 33075578; PMCID: PMC7566821.
  38. Chen F, Chen W, Chen J, Xu D, Xie W, Wang X, Xie Y. Clinical features and risk factors of COVID-19-associated liver injury and function: A retrospective analysis of 830 cases. Ann Hepatol. 2020 Oct 11:S1665-2681(20)30182-4. doi: 10.1016/j.aohep.2020.09.011. Epub ahead of print. PMID: 33053426; PMCID: PMC7548062.
  39. Zhong P, Xu J, Yang D, Shen Y, Wang L, Feng Y, Du C, Song Y, Wu C, Hu X, Sun Y. COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms. Signal Transduct Target Ther. 2020 Nov 2;5(1):256. doi: 10.1038/s41392-020-00373-7. PMID: 33139693; PMCID: PMC7605138.
  40. Chaibi S, Boussier J, Hajj WE, Abitbol Y, Taieb S, Horaist C, Jouannaud V, Wang P, Piquet J, Maurer C, Lahmek P, Nahon S. Liver function test abnormalities are associated with a poorer prognosis in Covid-19 patients: Results of a French cohort. Clin Res Hepatol Gastroenterol. 2020 Oct 19:S2210-7401(20)30297-7. doi: 10.1016/j.clinre.2020.10.002. Epub ahead of print. PMID: 33139241; PMCID: PMC7572046.
  41. Bin Arif T, Khalid S, Siddiqui MS, Hussain H, Sohail H. Incidence, patterns, risk factors, and histopathological findings of liver injury in coronavirus disease 2019 (COVID-19): a scoping review. Hong Kong Med J. 2020 Oct 30. doi: 10.12809/hkmj208732. Epub ahead of print. PMID: 33122448.
  42. Schmit G, Lelotte J, Vanhaebost J, Horsmans Y, Van Bockstal M, Baldin P. The Liver in COVID-19-Related Death: Protagonist or Innocent Bystander? Pathobiology. 2020 Oct 27:1-7. doi: 10.1159/000512008. Epub ahead of print. PMID: 33108789.
  43. Chueh TI, Zheng CM, Hou YC, Lu KC. Novel Evidence of Acute Kidney Injury in COVID-19. J Clin Med. 2020 Nov 3;9(11):E3547. doi: 10.3390/jcm9113547. PMID: 33153216.
  44. Hilbrands LB, Duivenvoorden R, Vart P, Franssen CFM, Hemmelder MH, Jager KJ, Kieneker LM, Noordzij M, Pena MJ, Vries H, Arroyo D, Covic A, Crespo M, Goffin E, Islam M, Massy ZA, Montero N, Oliveira JP, Roca Muñoz A, Sanchez JE, Sridharan S, Winzeler R, Gansevoort RT; ERACODA Collaborators. COVID-19-related mortality in kidney transplant and dialysis patients: results of the ERACODA collaboration. Nephrol Dial Transplant. 2020 Nov 1;35(11):1973-1983. doi: 10.1093/ndt/gfaa261. PMID: 33151337.
  45. Parmar MS. Acute Kidney Injury associated with COVID-19 - Cumulative Evidence and Rationale supporting Against Direct Kidney Injury (Infection). Nephrology (Carlton). 2020 Nov 5. doi: 10.1111/nep.13814. Epub ahead of print. PMID: 33150674.
  46. Aziz M, Haghbin H, Lee-Smith W, Goyal H, Nawras A, Adler DG. Gastrointestinal predictors of severe COVID-19: systematic review and meta-analysis. Ann Gastroenterol. 2020 Nov-Dec;33(6):615-630. doi: 10.20524/aog.2020.0527. Epub 2020 Jul 30. PMID: 33162738; PMCID: PMC7599357.
  47. Poynard T, Deckmyn O, Rudler M, Peta V, Ngo Y, Vautier M, Akhavan S, Calvez V, Franc C, Castille JM, Drane F, Sakka M, Bonnefont-Rousselot D, Lacorte JM, Saadoun D, Allenbach Y, Benveniste O, Gandjbakhch F, Mayaux J, Lucidarme O, Fautrel B, Ratziu V, Housset C, Thabut D, Cacoub P. Performance of serum apolipoprotein-A1 as a sentinel of Covid-19. PLoS One. 2020 Nov 20;15(11):e0242306. doi: 10.1371/journal.pone.0242306. PMID: 33216772.
  48. Luglio M, Tannuri U, de Carvalho WB, Bastos KLM, Rodriguez IS, Johnston C, Delgado AF. COVID-19 and Liver Damage: Narrative Review and Proposed Clinical Protocol for Critically ill Pediatric Patients. Clinics (Sao Paulo). 2020 Nov 11;75:e2250. doi: 10.6061/clinics/2020/e2250. PMID: 33206767; PMCID: PMC7603295.
  49. Salah HM, Arthur JM, Mehta JL. Implications of renal ACE2 expression in the age of COVID-19. Eur Heart J. 2020 Nov 17:ehaa872. doi: 10.1093/eurheartj/ehaa872. Epub ahead of print. PMID: 33205204.
  50. Jiang X, Eales JM, Scannali D, Nazgiewicz A, Prestes P, Maier M, Denniff M, Xu X, Saluja S, Cano-Gamez E, Wystrychowski W, Szulinska M, Antczak A, Byars S, Skrypnik D, Glyda M, Król R, Zywiec J, Zukowska-Szczechowska E, Burrell LM, Woolf AS, Greenstein A, Bogdanski P, Keavney B, Morris AP, Heagerty A, Williams B, Harrap SB, Trynka G, Samani NJ, Guzik TJ, Charchar FJ, Tomaszewski M. Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney. Eur Heart J. 2020 Oct 27:ehaa794. doi: 10.1093/eurheartj/ehaa794. Epub ahead of print. PMID: 33206176; PMCID: PMC7665509.
  51. Liu SL, Wang SY, Sun YF, Jia QY, Yang CL, Cai PJ, Li JY, Wang L, Chen Y. Expressions of SAA, CRP, and FERR in different severities of COVID-19. Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):11386-11394. doi: 10.26355/eurrev_202011_23631. PMID: 33215460.
  52. Rasch S, Herner A, Schmid RM, Huber W, Lahmer T. High lipasemia is frequent in Covid-19 associated acute respiratory distress syndrome. Pancreatology. 2020 Nov 29:S1424-3903(20)30856-5. doi: 10.1016/j.pan.2020.11.023. Epub ahead of print. PMID: 33277183.
  53. Shetty AA, Tawhari I, Safar-Boueri L, Seif N, Alahmadi A, Gargiulo R, Aggarwal V, Usman I, Kisselev S, Gharavi AG, Kanwar Y, Quaggin SE. COVID-19-Associated Glomerular Disease. J Am Soc Nephrol. 2020 Nov 19:ASN.2020060804. doi: 10.1681/ASN.2020060804. Epub ahead of print. PMID: 33214201.
  54. Piñeiro GJ, Molina-Andújar A, Hermida E, Blasco M, Quintana LF, Rojas GM, Mercadal J, Castro P, Sandoval E, Andrea R, Fernández J, Badia JR, Soriano A, Poch E; Hospital Clínic Critical Care COVID-19 working group (CCCC). Severe acute kidney injury in critically ill COVID-19 patients. J Nephrol. 2021 Jan 2. doi: 10.1007/s40620-020-00918-7. Epub ahead of print. PMID: 33387345.
  55. Liu R, Zhao L, Cheng X, Huan H, Li C, Li D, Liu A, Gao G, Zhou F, Liu F, Jiang Y, Zhu C, Xia Y. Clinical Characteristics of COVID-19 Patients with Hepatitis B Virus Infection - a Retrospective Study. Liver Int. 2020 Dec 22. doi: 10.1111/liv.14774. Epub ahead of print. PMID: 33351265.
  56. Mendizabal M, Piñero F, Ridruejo E, Anders M, Silveyra MD, Torre A, Montes P, Urzúa A, Pages J, Toro LG, Díaz J, Ballerga EG, Miranda-Zazueta G, Peralta M, Gutiérrez I, Michelato D, Venturelli MG, Varón A, Pozo EV, Tagle M, García M, Tassara A, Brutti J, García SR, Bustios C, Escajadillo N, Macias Y, la Tijera FH, Gómez AJ, Dominguez A, Barradas MC, Contreras F, Scarpin A, Schinoni MI, Toledo C, Girala M, Mainardi V, Sanchez A, Bessone F, Rubinstein F, O Silva M. Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission. Ann Hepatol. 2020 Dec 21:100298. doi: 10.1016/j.aohep.2020.100298. Epub ahead of print. PMID: 33359234.
  57. Hendra H, Vajgel G, Antonelou M, Neradova A, Manson B, Clark SG, Kostakis ID, Caplin B, Salama AD. Identifying prognostic risk factors for poor outcome following COVID-19 disease among in-centre haemodialysis patients: role of inflammation and frailty. J Nephrol. 2021 Jan 30. doi: 10.1007/s40620-020-00960-5. Epub ahead of print. PMID: 33515380.
  58. Chaudhri I, Koraishy FM, Bolotova O, Yoo J, Marcos LA, Taub E, Sahib H, Bloom M, Ahmad S, Skopicki H, Mallipattu SK. Outcomes Associated with the Use of Renin-Angiotensin-Aldosterone System Blockade in Hospitalized Patients with SARS-CoV-2 Infection. Kidney360. 2020 Aug;1(8):801-809. doi: 10.34067/kid.0003792020. Epub 2020 Aug 27. PMID: 33345195; PMCID: PMC7748256.

 

 

 

 

 

Pediatrics:

  1. Rodriguez-Smith JJ, et al. Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort study. Lancet Rheumatol. 2021 Jun 8. doi: 10.1016/S2665-9913(21)00139-9. Epub ahead of print. PMID: 34124694; PMCID: PMC8186852.
  2. Cotugno N, et al. Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology. Pediatr Allergy Immunol. 2021 Jun 26. doi: 10.1111/pai.13585. Epub ahead of print. PMID: 34174102.
  3. Miller MJ, et al. Severe Acute Respiratory Syndrome Coronavirus 2 Testing Trends Among Persons Aged <18 Years in an Outpatient Pediatric Practice - Metropolitan Atlanta, Georgia, May-December 2020. J Adolesc Health. 2021 Jul;69(1):144-148. doi: 10.1016/j.jadohealth.2021.04.010. PMID: 34172138.
  4. Angurana ASK, et al. Intensive care needs and short-term outcome of Multisystem Inflammatory Syndrome in Children (MIS-C): Experience from North India. J Trop Pediatr. 2021 Jun 25:fmab055. doi: 10.1093/tropej/fmab055. Epub ahead of print. PMID: 34170328.
  5. Calitri C, et al. Gastrointestinal involvement in paediatric COVID-19 - from pathogenesis to clinical management: A comprehensive review. World J Gastroenterol. 2021 Jun 21;27(23):3303-3316. doi: 10.3748/wjg.v27.i23.3303. PMID: 34163113; PMCID: PMC8218363.
  6. Tannoury TE, et al. Cardiac manifestations and short-term outcomes of Multisystem Inflammatory Syndrome in Middle Eastern Children during the COVID-19 pandemic: A case series. Cardiol Young. 2021 Jun 17:1-13. doi: 10.1017/S1047951121002614. Epub ahead of print. PMID: 34134808.
  7. Son MBF; Overcoming COVID-19 Investigators. Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes. N Engl J Med. 2021 Jun 16. doi: 10.1056/NEJMoa2102605. Epub ahead of print. PMID: 34133855.
  8. Holm M, et al. Multisystem inflammatory syndrome in children occurred in one of four thousand children with severe acute respiratory syndrome coronavirus-2. Acta Paediatr. 2021 Jun 15. doi: 10.1111/apa.15985. Epub ahead of print. PMID: 34129731.
  9. Felsenstein S, et al Cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS. Clin Immunol. 2021 Jun 9;229:108780. doi: 10.1016/j.clim.2021.108780. Epub ahead of print. PMID: 34118400.
  10. Haslak F, et al. Clinical features and outcomes of 76 patients with COVID-19-related multi-system inflammatory syndrome in children. Clin Rheumatol. 2021 Jun 5:1–12. doi: 10.1007/s10067-021-05780-x. Epub ahead of print. PMID: 34089099; PMCID: PMC8178032.
  11. Zhao Y, et al. Cardiac markers of multisystem inflammatory syndrome in children (MIS-C) in COVID-19 patients: A meta-analysis. Am J Emerg Med. 2021 May 18;49:62-70. doi: 10.1016/j.ajem.2021.05.044. Epub ahead of print. PMID: 34082189; PMCID: PMC8129790.
  12. Henry BM, Lippi G, Plebani M. Laboratory abnormalities in children with novel coronavirus disease 2019. Clinical Chemistry and Laboratory Medicine (CCLM). 2020 Mar 16. PMID: 32172227
  13. Cao J, Devaraj S. COVID-19 in Pediatrics: A Laboratory Perspective. The Journal of Applied Laboratory Medicine. 2020 Apr 15.
  14. Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID‐19 infection: Different points from adults. Pediatric pulmonology. 2020 Mar 5. PMID:32134205
  15. Pedersen SF, Ho YC. SARS-CoV-2: A Storm is Raging. The Journal of Clinical Investigation. 2020 Mar 27. PMID: 32217834
  16. Dong L, Tian J, He S, Zhu C, Wang J, Liu C, Yang J. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. Jama. 2020 Mar 26. PMID:32215581
  17. Zeng H, Xu C, Fan J, Tang Y, Deng Q, Zhang W, Long X. Antibodies in infants born to mothers with COVID-19 pneumonia. Jama. 2020 Mar 26. PMID: 32215589
  18. Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Li J, Zhao D, Xu D, Gong Q, Liao J. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. The Lancet. 2020 Mar 7;395(10226):809-15. PMID: 32151335
  19. Jiang S, Liu P, Xiong G, Yang Z, Wang M, Li Y, Yu XJ. Coinfection of SARS-CoV-2 and multiple respiratory pathogens in children. Clinical Chemistry and Laboratory Medicine (CCLM). 2020 Apr 16;1(ahead-of-print). PMID: 32301747
  20. Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, Zhang W, Wang Y, Bao S, Li Y, Wu C. SARS-CoV-2 infection in children. New England Journal of Medicine. 2020 Mar 18. PMID: 32187458
  21. Liu W, Wang J, Li W, Zhou Z, Liu S, Rong Z. Clinical characteristics of 19 neonates born to mothers with COVID-19. Frontiers of Medicine. 2020 Apr 13:1-6. PMID: 32285380
  22. Nathan N, Prevost B, Corvol H. Atypical presentation of COVID-19 in young infants. The Lancet. 2020 Apr 27. PMID: 32353326
  23. Zhang Y, Xu J, Jia R, et al. Protective humoral immunity in SARS-CoV-2 infected pediatric patients]. Cell Mol Immunol. 2020 May 7. PMID: 32382126
  24. Zimmermann P, Curtis N. COVID-19 in Children, Pregnancy and Neonates: A Review of Epidemiologic and Clinical Features. The Pediatric Infectious Disease Journal. 2020 Jun 1;39(6):469-77. PMID: 32398569
  25. Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. The Lancet. 2020 May 7. PMID: 32386565
  26. Jones VG, Mills M, Suarez D, Hogan CA, Yeh D, Segal JB, Nguyen EL, Barsh GR, Maskatia S, Mathew R. COVID-19 and Kawasaki disease: novel virus and novel case. Hospital Pediatrics. 2020 May 1:hpeds-2020. PMID: 32265235
  27. Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. The Lancet. 2020 May 7. PMID: 32386565
  28. DeBiasi RL, Song X, Delaney M, Bell M, Smith K, Pershad J, Ansusinha E, Hahn A, Hamdy R, Harik N, Hanisch B. Severe COVID-19 in children and young adults in the Washington, DC metropolitan region. The Journal of Pediatrics. 2020 May 13. PMID: 32405091
  29. Shekerdemian LS, Mahmood NR, Wolfe KK, Riggs BJ, Ross CE, McKiernan CA, Heidemann SM, Kleinman LC, Sen AI, Hall MW, Priestley MA. Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units. JAMA pediatrics. 2020 May 11. PMID: 32392288
  30. https://www.who.int/news-room/commentaries/detail/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19
  31. Henry BM, Benoit SW, de Oliveira MH, Hsieh WC, Benoit J, Ballout RA, Plebani M, Lippi G. Laboratory Abnormalities in Children with Mild and Severe Coronavirus Disease 2019 (COVID-19): a pooled analysis and review. Clinical Biochemistry. 2020 May 27. PMID: 32473151
  32. Batu ED, Özen S. Implications of COVID-19 in pediatric rheumatology [published online ahead of print, 2020 Jun 4]. Rheumatol Int. 2020;10.1007/s00296-020-04612-6. doi:10.1007/s00296-020-04612-6. PMID: 32500409
  33. Colonna C, Spinelli F, Monzani NA, Ceriotti F, Gelmetti C. Chilblains in children in the time of Covid-19: new evidence with serology assay [published online ahead of print, 2020 Jun 13]. Pediatr Dermatol. 2020;1111/pde.14269. doi:10.1111/pde.14269
  34. Götzinger, Florian & Santiago García, Begoña & Noguera, Antoni & Lanaspa, Miguel & Carducci, Francesca & Gabrovska, Natalia & Velizarova, Svetlana & Prunk, Petra & Osterman, Veronika & Krivec, Uros & Vecchio, Andrea & Shingadia, Delane & Soriano-Arandes, Antoni & Melendo, Susana & Lanari, Marcello & Pierantoni, Luca & Wagner, Noémie & L'Huillier, Arnaud. (2020). COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study. The Lancet Child & Adolescent Health. 10.1016/S2352-4642(20)30177-2.
  35. Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents [published online ahead of print, 2020 Jun 29]. N Engl J Med. 2020;NEJMoa2021680. doi:10.1056/NEJMoa2021680
  36. Kache S, Chisti MJ, Gumbo F, et al. COVID-19 PICU guidelines: for high- and limited-resource settings [published online ahead of print, 2020 Jul 7]. Pediatr Res. 2020;10.1038/s41390-020-1053-9. doi:10.1038/s41390-020-1053-9
  37. Moraleda C, Serna-Pascual M, Soriano-Arandes A, et al. Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain [published online ahead of print, 2020 Jul 25]. Clin Infect Dis. 2020;ciaa1042. doi:10.1093/cid/ciaa1042
  38. Henderson LA, Canna SW, Friedman KG, et al. American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 and Hyperinflammation in COVID-19. Version 1 [published online ahead of print, 2020 Jul 23]. Arthritis Rheumatol. 2020;10.1002/art.41454. doi:10.1002/art.41454
  39. Lee PY, Day-Lewis M, Henderson LA, et al. Distinct clinical and immunological features of SARS-COV-2-induced multisystem inflammatory syndrome in children [published online ahead of print, 2020 Jul 23]. J Clin Invest. 2020;141113. doi:10.1172/JCI141113
  40. Heald-Sargent T, Muller WJ, Zheng X, Rippe J, Patel AB, Kociolek LK. Age-related differences in nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) levels in patients with mild to moderate coronavirus disease 2019 (COVID-19). JAMA pediatrics. 2020. PMID: 32745201
  41. COVID-19–Associated Multisystem Inflammatory Syndrome in Children — United States, March–July 2020. https://www.cdc.gov/mmwr/volumes/69/wr/mm6932e2.htm?s_cid=mm6932e2_w
  42. Bar-Or D, Rael LT, Brody EN. Insights into pediatric multi-system inflammatory syndrome and COVID-19 [published online ahead of print, 2020 Jul 14]. Clin Chim Acta. 2020;510:121-122. doi:10.1016/j.cca.2020.07.025
  43. Lara D, Young T, Del Toro K, et al. Acute Fulminant Myocarditis in a Pediatric Patient With COVID-19 Infection. Pediatrics. 2020;146(2):e20201509. doi:10.1542/peds.2020-1509
  44. Pérez-Martinez A, Guerra-García P, Melgosa M, et al. Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain [published online ahead of print, 2020 Aug 29].Eur J Pediatr. 2020;10.1007/s00431-020-03793-3. doi:10.1007/s00431-020-03793-3
  45. Peck JL. COVID-19: Impacts and Implications for Pediatric Practice [published online ahead of print, 2020 Jul 9].J Pediatr Health Care. 2020;S0891-5245(20)30177-2. doi:10.1016/j.pedhc.2020.07.004
  46. Ciprandi G, Licari A, Filippelli G, Tosca MA, Marseglia GL. Children and adolescents with allergy and/or asthma seem to be protected from coronavirus disease 2019.Ann Allergy Asthma Immunol. 2020;125(3):361-362. doi:10.1016/j.anai.2020.06.001
  47. Patel AB, Clifford A, Creaden J, et al. SARS-CoV-2 Point Prevalence among Asymptomatic Hospitalized Children and Subsequent Healthcare Worker Evaluation [published online ahead of print, 2020 Aug 28].J Pediatric Infect Dis Soc. 2020;piaa102. doi:10.1093/jpids/piaa102
  48. Han MS, Choi EH, Chang SH, et al. Clinical Characteristics and Viral RNA Detection in Children With Coronavirus Disease 2019 in the Republic of Korea [published online ahead of print, 2020 Aug 28].JAMA Pediatr. 2020;10.1001/jamapediatrics.2020.3988. doi:10.1001/jamapediatrics.2020.3988
  49. Dhir SK, Kumar J, Meena J, Kumar P. Clinical Features and Outcome of SARS-CoV-2 Infection in Neonates: A Systematic Review [published online ahead of print, 2020 Aug 28].J Trop Pediatr. 2020;fmaa059. doi:10.1093/tropej/fmaa059
  50. Mamishi S, Movahedi Z, Mohammadi M, et al. Multisystem Inflammatory Syndrome Associated with SARS-CoV-2 Infection in 45 Children: A First Report from Iran [published online ahead of print, 2020 Aug 28].Epidemiol Infect. 2020;1-16. doi:10.1017/S095026882000196X
  51. Pang J, Boshier FAT, Alders N, Dixon G, Breuer J. SARS-CoV-2 Polymorphisms and Multisystem Inflammatory Syndrome in Children (MIS-C) [published online ahead of print, 2020 Sep 9]. Pediatrics. 2020;e2020019844. doi:10.1542/peds.2020-019844
  52. Tam H, El Tal T, Go E, Yeung RSM. Pediatric inflammatory multisystem syndrome temporally associated with COVID-19: a spectrum of diseases with many names [published online ahead of print, 2020 Sep 9]. CMAJ. 2020;cmaj.201600. doi:10.1503/cmaj.201600
  53. Do LAH, Anderson J, Mulholland EK, Licciardi PV. Can data from paediatric cohorts solve the COVID-19 puzzle?. PLoS Pathog. 2020;16(9):e1008798. Published 2020 Sep 9. doi:10.1371/journal.ppat.1008798
  54. Han MS, Choi EH, Chang SH, et al. Clinical Characteristics and Viral RNA Detection in Children With Coronavirus Disease 2019 in the Republic of Korea [published online ahead of print, 2020 Aug 28]. JAMA Pediatr. 2020;10.1001/jamapediatrics.2020.3988. doi:10.1001/jamapediatrics.2020.3988
  55. Yonker LM, Neilan AM, Bartsch Y, et al. Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses [published online ahead of print, 2020 Aug 18]. J Pediatr. 2020;S0022-3476(20)31023-4. doi:10.1016/j.jpeds.2020.08.037
  56. Sinaei R, Pezeshki S, Parvaresh S, Sinaei R. Why COVID-19 is less frequent and severe in children: a narrative review. World J Pediatr. 2020 Sep 25. doi: 10.1007/s12519-020-00392-y. Epub ahead of print. PMID: 32978651.
  57. Minocha PK, Phoon CKL, Verma S, Singh RK. Cardiac Findings in Pediatric Patients With Multisystem Inflammatory Syndrome in Children Associated With COVID-19. Clin Pediatr (Phila). 2020 Sep 25:9922820961771. doi: 10.1177/0009922820961771. Epub ahead of print. PMID: 32975439.
  58. Venturini E, Montagnani C, Garazzino S, Donà D, Pierantoni L, Lo Vecchio A, Nicolini G, Bianchini S, Krzysztofiak A, Galli L, Villani A, Castelli-Gattinara G; Italian SITIP-SIP SARS-Cov-2 pediatric infection study group. Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious D Ital J Pediatr. 2020 Sep 24;46(1):139. doi: 10.1186/s13052-020-00900-w. PMID: 32972435.
  59. Harwood R, Allin B, Jones CE, Whittaker E, Ramnarayan P, Ramanan AV, Kaleem M, Tulloh R, Peters MJ, Almond S, Davis PJ, Levin M, Tometzki A, Faust SN, Knight M, Kenny S; PIMS-TS National Consensus Management Study Group. A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. Lancet Child Adolesc Health. 2020 Sep 18:S2352-4642(20)30304-7. doi: 10.1016/S2352-4642(20)30304-7. Epub ahead of print. PMID: 32956615.
  60. Melé M, Henares D, Pino R, Asenjo S, Matamoros R, Fumadó V, Fortuny C, García-García JJ, Jordan I, Brotons P, Muñoz-Almagro C, F-de-Sevilla M, Launes C; Kids-Corona Paediatric Hospitalist group. Low impact of SARS-CoV-2 infection among paediatric acute respiratory disease hospitalizations. J Infect. 2020 Oct 21:S0163-4453(20)30655-1. doi: 10.1016/j.jinf.2020.10.013. Epub ahead of print. PMID: 33098956.
  61. Al-Ghafry M, Aygun B, Appiah-Kubi A, Vlachos A, Ostovar G, Capone C, Sweberg T, Palumbo N, Goenka P, Wolfe LW, Lipton JM, Acharya SS. Are children with SARS-CoV-2 infection at high risk for thrombosis? Viscoelastic testing and coagulation profiles in a case series of pediatric patients. Pediatr Blood Cancer. 2020 Dec;67(12):e28737. doi: 10.1002/pbc.28737. PMID: 33098753.
  62. Bolaños-Almeida CE, Espitia Segura OM. Clinical and Epidemiologic Analysis of COVID-19 Children Cases in Colombia PEDIACOVID. Pediatr Infect Dis J. 2020 Oct 20. doi: 10.1097/INF.0000000000002952. Epub ahead of print. PMID: 33093428.
  63. Stevens JP, Brownell JN, Freeman AJ, Bashaw H. COVID-19-associated Multisystem Inflammatory Syndrome in Children Presenting as Acute Pancreatitis. J Pediatr Gastroenterol Nutr. 2020 Nov;71(5):669-671. doi: 10.1097/MPG.0000000000002860. PMID: 33093376.
  64. Friedman KG, Harrild DM, Newburger JW. Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children: A Call to Action. J Am Coll Cardiol. 2020 Oct 27;76(17):1962-1964. doi: 10.1016/j.jacc.2020.09.002. PMID: 33092731; PMCID: PMC7572056. 
  65. Hurst JH, Heston SM, Chambers HN, Cunningham HM, Price MJ, Suarez L, Crew CG, Bose S, Aquino JN, Carr ST, Griffin SM, Smith SH, Jenkins K, Pfeiffer TS, Rodriguez J, DeMarco CT, De Naeyer NA, Gurley TC, Louzao R, Zhao C, Cunningham CK, Steinbach WJ, Denny TN, Lugo DJ, Moody MA, Permar SR, Rotta AT, Turner NA, Walter EB, Woods CW, Kelly MS. SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study. Clin Infect Dis. 2020 Nov 3:ciaa1693. doi: 10.1093/cid/ciaa1693. Epub ahead of print. PMID: 33141180.
  66. Kociolek LK, Muller WJ, Yee R, Dien Bard J, Brown CA, Revell P, Wardell H, Savage TJ, Jung S, Dominguez S, Parikh BA, Jerris RC, Kehl SC, Campigotto A, Bender JM, Zheng X, Muscat E, Linam M, Abuogi L, Smith C, Graff K, Hernandez-Leyva A, Williams D, Pollock NR. Comparison of upper respiratory viral load distributions in asymptomatic and symptomatic children diagnosed with SARS-CoV-2 infection in pediatric hospital testing programs. J Clin Microbiol. 2020 Oct 22:JCM.02593-20. doi: 10.1128/JCM.02593-20. Epub ahead of print. PMID: 33093026.
  67. Kosmeri C, Koumpis E, Tsabouri S, Siomou E, Makis A. Hematological manifestations of SARS-CoV-2 in children. Pediatr Blood Cancer. 2020 Dec;67(12):e28745. doi: 10.1002/pbc.28745. Epub 2020 Oct 3. PMID: 33009893; PMCID: PMC7646039.
  68. Weisberg SP, Connors TJ, Zhu Y, Baldwin MR, Lin WH, Wontakal S, Szabo PA, Wells SB, Dogra P, Gray J, Idzikowski E, Stelitano D, Bovier FT, Davis-Porada J, Matsumoto R, Poon MML, Chait M, Mathieu C, Horvat B, Decimo D, Hudson KE, Zotti FD, Bitan ZC, La Carpia F, Ferrara SA, Mace E, Milner J, Moscona A, Hod E, Porotto M, Farber DL. Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum. Nat Immunol. 2020 Nov 5. doi: 10.1038/s41590-020-00826-9. Epub ahead of print. PMID: 33154590.
  69. Gupta R, Beg S, Jain A, Bhatnagar S. Paediatric COVID-19 and the GUT. Indian J Med Microbiol. 2020 Jul-Dec;38(3 & 4):261-264. doi: 10.4103/ijmm.IJMM_20_331. PMID: 33154233.
  70. Kabeerdoss J, Pilania RK, Karkhele R, Kumar TS, Danda D, Singh S. Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management. Rheumatol Int. 2020 Nov 21. doi: 10.1007/s00296-020-04749-4. Epub ahead of print. PMID: 33219837.
  71. Alsharrah D, Alhaddad F, Alyaseen M, Aljamaan S, Almutairi N, Ayed M, Papenburg J, Alghounaim M. Clinical Characteristics of Pediatric SARS-CoV-2 Infection and Coronavirus Disease 2019 (COVID-19) in Kuwait. J Med Virol. 2020 Nov 20. doi: 10.1002/jmv.26684. Epub ahead of print. PMID: 33219559.
  72. Carsetti R, Quintarelli C, Quinti I, Piano Mortari E, Zumla A, Ippolito G, Locatelli F. The immune system of children: the key to understanding SARS-CoV-2 susceptibility? Lancet Child Adolesc Health. 2020 Jun;4(6):414-416. doi: 10.1016/S2352-4642(20)30135-8. Epub 2020 May 6. PMID: 32458804; PMCID: PMC7202830.
  73. Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, Behrens EM, Ferris A, Kernan KF, Schulert GS, Seo P, F Son MB, Tremoulet AH, Yeung RSM, Mudano AS, Turner AS, Karp DR, Mehta JJ. American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 1. Arthritis Rheumatol. 2020 Jul 23:10.1002/art.41454. doi: 10.1002/art.41454. Epub ahead of print. PMID: 32705809; PMCID: PMC7405113.
  74. Oliva Rodríguez-Pastor S, Martín Pedraz L, Carazo Gallego B, Galindo Zavala R, Lozano Sánchez G, de Toro Pseinado I, Rodriguez Benjumea M, Mejias A, Cuadros EN. Skin Manifestations During the COVID-19 Pandemic in the Pediatric Emergency Department. Pediatr Int. 2020 Dec 5. doi: 10.1111/ped.14568. Epub ahead of print. PMID: 33278056.
  75. Uda K, Okita K, Soneda K, Taniguchi K, Horikoshi Y. Kawasaki disease following coronavirus disease 2019 with prolonged fecal viral shedding. Pediatr Int. 2020 Dec 5. doi: 10.1111/ped.14452. Epub ahead of print. PMID: 33278321.
  76. Rankin DA, Talj R, Howard LM, Halasa NB. Epidemiologic trends and characteristics of SARS-CoV-2 infections among children in the United States. Curr Opin Pediatr. 2020 Dec 4. doi: 10.1097/MOP.0000000000000971. Epub ahead of print. PMID: 33278112.
  77. Kamidani S, Rostad CA, Anderson EJ. COVID-19 vaccine development: a pediatric perspective. Curr Opin Pediatr. 2020 Dec 4. doi: 10.1097/MOP.0000000000000978. Epub ahead of print. PMID: 33278108.
  78. Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, Behrens EM, Ferris A, Kernan KF, Schulert GS, Seo P, Son MBF, Tremoulet AH, Yeung RSM, Mudano AS, Turner AS, Karp DR, Mehta JJ. American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 and Hyperinflammation in COVID-19. Version 2. Arthritis Rheumatol. 2020 Dec 5. doi: 10.1002/art.41616. Epub ahead of print. PMID: 33277976.
  79. Kwak JH, Lee SY, Choi JW; Korean Society of Kawasaki Disease. Clinical features, diagnosis, and outcomes of multisystem inflammatory syndrome in children associated with coronavirus disease 2019. Clin Exp Pediatr. 2020 Dec 30. doi: 10.3345/cep.2020.01900. Epub ahead of print. PMID: 33445833.
  80. Funk AL, Florin TA, Dalziel SR, Mintegi S, Salvadori MI, Tancredi DJ, Neuman MI, Payne DC, Plint AC, Klassen TP, Malley R, Ambroggio L, Kim K, Kuppermann N, Freedman SB. Prospective cohort study of children with suspected SARS-CoV-2 infection presenting to paediatric emergency departments: a Paediatric Emergency Research Networks (PERN) Study Protocol. BMJ Open. 2021 Jan 15;11(1):e042121. doi: 10.1136/bmjopen-2020-042121. PMID: 33452195.
  81. Szépfalusi Z, Schmidthaler K, Sieber J, Kopanja S, Götzinger F, Schoof A, Hoz J, Willinger B, Makristathis A, Weseslindtner L, Stiasny K, Bohle B, Krotka P, Graf A, Frischer T. Lessons from low seroprevalence of SARS-CoV-2 antibodies in schoolchildren: a cross-sectional study. Pediatr Allergy Immunol. 2021 Jan 29. doi: 10.1111/pai.13459. Epub ahead of print. PMID: 33512035.
  82. Esteve-Sole A, Anton J, Pino-Ramírez RM, Sanchez-Manubens J, Fumadó V, Fortuny C, Rios-Barnes M, Sanchez-de-Toledo J, Girona-Alarcón M, Mosquera JM, Ricart S, Launes C, de Sevilla MF, Jou C, Muñoz-Almagro C, González-Roca E, Vergara A, Carrillo J, Juan M, Cuadras D, Noguera-Julian A, Jordan I, Alsina L. Similarities and differences between the immunopathogenesis of COVID-19-related pediatric inflammatory multisystem syndrome and Kawasaki disease. J Clin Invest. 2021 Jan 26:144554. doi: 10.1172/JCI144554. Epub ahead of print. PMID: 33497356.
  83. Cherqaoui B, Koné-Paut I, Yager H, Bourgeois FL, Piram M. Delineating phenotypes of Kawasaki disease and SARS-CoV-2-related inflammatory multisystem syndrome: A French study and literature review. Rheumatology (Oxford). 2021 Jan 25:keab026. doi: 10.1093/rheumatology/keab026. Epub ahead of print. PMID: 33493353.
  84. Girona-Alarcon M, Bobillo-Perez S, Sole-Ribalta A, Hernandez L, Guitart C, Suarez R, Balaguer M, Cambra FJ, Jordan I; KIDS-Corona study group; Kids Corona Platform. The different manifestations of COVID-19 in adults and children: a cohort study in an intensive care unit. BMC Infect Dis. 2021 Jan 20;21(1):87. doi: 10.1186/s12879-021-05786-5. PMID: 33472588; PMCID: PMC7816131.
  85. Abdel-Haq N, Asmar BI, Deza Leon MP, McGrath EJ, Arora HS, Cashen K, Tilford B, Charaf Eddine A, Sethuraman U, Ang JY. SARS-CoV-2-associated multisystem inflammatory syndrome in children: clinical manifestations and the role of infliximab treatment. Eur J Pediatr. 2021 Jan 16:1–11. doi: 10.1007/s00431-021-03935-1. Epub ahead of print. PMID: 33452570; PMCID: PMC7810600.

 

 

 

 

 

Maternal:

  1. Poon LC, Yang H, Kapur A, Melamed N, Dao B, Divakar H, McIntyre HD, Kihara AB, Ayres‐de‐Campos D, Ferrazzi EM, Di Renzo GC. Global interim guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals. International Journal of Gynecology & Obstetrics. 2020 Apr 4. PMID: 32248521
  2. Mullins E, Evans D, Viner RM, O'Brien P, Morris E. Coronavirus in pregnancy and delivery: rapid review. Ultrasound in Obstetrics & Gynecology. 2020 Mar 17. PMID: 32180292
  3. Summary of guidelines related to obstetrics and gynaecology published by the ObG Project.  Coronavirus and Pregnancy: CDC Guidance and Professional Recommendations
  4. Golden TN, Simmons RA. Maternal and Neonatal Response to COVID-19 [published online ahead of print, 2020 Jun 23]. Am J Physiol Endocrinol Metab. 2020;1152/ajpendo.00287.2020. doi:10.1152/ajpendo.00287.2020
  5. Molina LP, Chow SK, Nickel A, Love JE. Prolonged Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in an Obstetric Patient With Antibody Seroconversion [published online ahead of print, 2020 Jul 21]. Obstet Gynecol. 2020;10.1097/AOG.0000000000004086. doi:10.1097/AOG.0000000000004086
  6. Barbero P, Mugüerza L, Herraiz I, et al. SARS-CoV-2 in pregnancy: characteristics and outcomes of hospitalized and non-hospitalized women due to COVID-19 [published online ahead of print, 2020 Jul 20]. J Matern Fetal Neonatal Med. 2020;1-7. doi:10.1080/14767058.2020.1793320
  7. Ashraf MA, Keshavarz P, Hosseinpour P, et al. Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the Possibility of Vertical Transmission. J Reprod Infertil. 2020;21(3):157-168.
  8. Takemoto MLS, Menezes MO, Andreucci CB, et al. Maternal mortality and COVID-19 [published online ahead of print, 2020 Jul 16]. J Matern Fetal Neonatal Med. 2020;1-7. doi:10.1080/14767058.2020.1786056
  9. Hessami K, Homayoon N, Hashemi A, Vafaei H, Kasraeian M, Asadi N. COVID-19 and maternal, fetal and neonatal mortality: a systematic review [published online ahead of print, 2020 Aug 16]. J Matern Fetal Neonatal Med. 2020;1-6. doi:10.1080/14767058.2020.1806817
  10. Takemoto MLS, Menezes MO, Andreucci CB, et al. Clinical characteristics and risk factors for mortality in obstetric patients with severe COVID-19 in Brazil: a surveillance database analysis [published online ahead of print, 2020 Aug 16]. BJOG. 2020;10.1111/1471-0528.16470. doi:10.1111/1471-0528.16470
  11. Dubey P, Reddy SY, Manuel S, Dwivedi AK. Maternal and neonatal characteristics and outcomes among COVID-19 infected women: An updated systematic review and meta-analysis [published online ahead of print, 2020 Jul 22]. Eur J Obstet Gynecol Reprod Biol. 2020;252:490-501. doi:10.1016/j.ejogrb.2020.07.034
  12. Mongula JE, Frenken MWE, van Lijnschoten G, et al. COVID-19 during pregnancy: non-reassuring fetal heart rate, placental pathology and coagulopathy [published online ahead of print, 2020 Aug 27].Ultrasound Obstet Gynecol. 2020;10.1002/uog.22189. doi:10.1002/uog.22189
  13. Kadir RA, Kobayashi T, Iba T, et al. COVID-19 Coagulopathy in Pregnancy: Critical Review, Preliminary Recommendations and ISTH Registry - Communication from the ISTH SSC for Women's Health [published online ahead of print, 2020 Aug 26].J Thromb Haemost. 2020;10.1111/jth.15072. doi:10.1111/jth.15072
  14. Massarotti C, Adriano M, Cagnacci A, et al. Asymptomatic SARS-CoV-2 infections in pregnant patients in an Italian city during complete lockdown [published online ahead of print, 2020 Aug 25].J Med Virol. 2020;10.1002/jmv.26458. doi:10.1002/jmv.26458
  15. Pirkle CM. Evidence based care for pregnant women with covid-19. BMJ. 2020;370:m3510. Published 2020 Sep 9. doi:10.1136/bmj.m3510
  16. Gao X, Wang S, Zeng W, et al. Clinical and immunological features among COVID-19 affected mother-infant pairs: antibodies to SARS- CoV- 2 detected in breast milk [published online ahead of print, 2020 Sep 1]. New Microbes New Infect. 2020;100752. doi:10.1016/j.nmni.2020.100752
  17. Lai YJ, Chang CM, Lin CK, et al. Severe acute respiratory syndrome coronavirus-2 and the deduction effect of angiotensin-converting enzyme 2 in pregnancy. J Chin Med Assoc. 2020;83(9):812-816. doi:10.1097/JCMA.0000000000000362
  18. Rana DMS, Usman MM, Alam DMM, et al. First trimester miscarriage in a pregnant woman infected with COVID-19 in Pakistan [published online ahead of print, 2020 Sep 4]. J Infect. 2020;S0163-4453(20)30587-9. doi:10.1016/j.jinf.2020.09.002
  19. Li W, Yu N, Kang Q, et al. Clinical manifestations and maternal and perinatal outcomes with COVID-19 [published online ahead of print, 2020 Sep 7]. Am J Reprod Immunol. 2020;e13340. doi:10.1111/aji.13340
  20. Delgado A, Santos Lira LC, Soligo Takemoto ML, Katz L, Amorim MM. Rates of Maternal and Perinatal Mortality and Vertical Transmission in Pregnancies Complicated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Co-V-2) Infection: A Systematic Review. Obstet Gynecol. 2020 Oct;136(4):849. doi: 10.1097/AOG.0000000000004111. PMID: 32976369.
  21. Di Mascio D, Sen C, Saccone G, Galindo A, Grünebaum A, Yoshimatsu J, Stanojevic M, Kurjak A, Chervenak F, Rodríguez Suárez MJ, Gambacorti-Passerini ZM, Baz MLAA, Aguilar Galán EV, López YC, De León Luis JA, Hernández IC, Herraiz I, Villalain C, Venturella R, Rizzo G, Mappa I, Gerosolima G, Hellmeyer L, Königbauer J, Ameli G, Frusca T, Volpe N, Luca Schera GB, Fieni S, Esposito E, Simonazzi G, Di Donna G, Youssef A, Della Gatta AN, Di Donna MC, Chiantera V, Buono N, Sozzi G, Greco P, Morano D, Bianchi B, Lombana Marino MG, Laraud F, Ramone A, Cagnacci A, Barra F, Gustavino C, Ferrero S, Ghezzi F, Cromi A, Laganà AS, Longo VL, Stollagli F, Sirico A, Lanzone A, Driul L, Cecchini D F, Xodo S, Rodriguez B, Mercado-Olivares F, Elkafrawi D, Sisti G, Esposito R, Coviello A, Cerbone M, Morlando M, Schiattarella A, Colacurci N, De Franciscis P, Cataneo I, Lenzi M, Sandri F, Buscemi R, Gattei G, Sala FD, Valori E, Rovellotti MC, Done E, Faron G, Gucciardo L, et al. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19. J Perinat Med. 2020 Sep 25:/j/jpme.ahead-of-print/jpm-2020-0355/jpm-2020-0355.xml. doi: 10.1515/jpm-2020-0355. Epub ahead of print. PMID: 32975205.
  22. Ashary N, Bhide A, Chakraborty P, Colaco S, Mishra A, Chhabria K, Jolly MK, Modi D. Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2. Front Cell Dev Biol. 2020 Aug 19;8:783. doi: 10.3389/fcell.2020.00783. PMID: 32974340; PMCID: PMC7466449.
  23. Veerus P, Salumets A, Naaber P, Krjutškov K, Tilk K, Laanpere M, Uusküla A. Seroprevalence of SARS-CoV-2 antibodies among pregnant women in Estonia: a call for epidemiological studies. Acta Obstet Gynecol Scand. 2020 Sep 24. doi: 10.1111/aogs.13995. Epub ahead of print. PMID: 32970836.
 
Copyright © 2000 - 2024 IFCC. All rights reserved.

Privacy Policy & Cookies Legal terms of use & copyright - privacy


Website developed by Insoft