Reference Intervals and Decision Limits (C-RIDL)

Membership

Terms of Reference

• To review current concepts of establishing reference intervals and decision limits and to prepare state-of-the-art position statements regarding new avenues
• To make available reference intervals and decision limits that respect the requirements of international directives such as the European IVD Directive 98/79, and relevant ISO standards
• To determine priority list of measurands (analytes) for which reference intervals and/or decision limits have to be developed, considering various factors, such as age, gender, ethnicity, and for which the greatest improvements in medical decision making are anticipated
• To monitor and evaluate currently proposed reference intervals for selected measurands (analytes) in the light of the concept of traceability and of the identification of the uncertainty
• To establish transferabilty protocols of reference intervals and decision limits, which take into consideration inter-routine laboratory method variations and achieve better applicability in clinical practice
• To collaborate with other organizations and/or to undertake establishment of reference intervals or decision limits for measurands (analytes) identified as a priority
• To work in close collaboration with other Cs and WGs of SD and other IFCC Divisions for the development and appropriate clinical utilization of reference intervals and decision limits

Current Projects

• Conduction of a new study to compare alternative approaches (conventional and big data) for the determination of reference intervals
• Creating a website to provide the reference intervals obtained from the global study for practice of Evidence Based Laboratory Medicine
• Preparation of a publication on comparison direct and indirect approaches for the determination of reference intervals.

The published 2 papers on Clinica Chimica Acta (CCA) about the results of Global Reference Intervals Study performed by C-RIDL are downloadable at following links:

"A global multicenter study on reference values"
Part 1: Assessment of methods for derivation and comparison of reference intervals
Part 2: Exploration of sources of variation across the countries

List of Corresponding Members, nominated by National Societies

List of Corresponding Members, nominated by Corporate Members

Committee Chair's contact

Dr. Thomas Streichert
Director Central Laboratory
Institute of Clinical Chemistry of the University of Cologne
Germany
E-mail: thomas.streichert@uk-koeln.de