Harmonization of Autoimmune Tests (C-HAT)

Membership

Terms of Reference

• To evaluate what are the main causes of variability for a number of diagnostically critical autoantibodies.
• To identify autoantibodies where a common calibrator could reduce the inter-assay variability 
• To identify or produce commutable materials that could be used as interim calibration material for autoantibody assays. 
• To produce well-characterised pure antibody preparations with known concentration and identity and use these to transfer values to a matrix preparation.  
• To evaluate the impact of new reference material on the variability of autoantibody tests and identify areas where further harmonisation would improve diagnostic accuracy.