Advancing excellence in laboratory medicine for better healthcare worldwide

Harmonization of Autoimmune Tests (C-HAT)


Name Position Country Term Time in Office
J. Sheldon Chair UK 2nd 2020 01 - 2022 12
X. Bossuyt Member BE 2nd 2020 01 - 2022 12
M.J. Fritzler Member CA 2nd 2020 01 - 2022 12
L. Wienholt Member AU 2nd 2020 01 - 2022 12
M. Rottmann Member/Roche  DE 2nd 2020 01 - 2022 12



Terms of Reference

  • To evaluate what are the main causes of variability for a number of diagnostically critical autoantibodies.
  • To identify autoantibodies where a common calibrator could reduce the inter-assay variability 
  • To identify or produce commutable materials that could be used as interim calibration material for autoantibody assays. 
  • To produce well-characterised pure antibody preparations with known concentration and identity and use these to transfer values to a matrix preparation.  
  • To evaluate the impact of new reference material on the variability of autoantibody tests and identify areas where further harmonisation would improve diagnostic accuracy.


List of Corresponding Members, nominated by National Societies


Name Full and Affiliate Member Societies
O.G. Carballo Confederación Unificada Bioquímica de la Republica Argentina (CUBRA)
A. Kozmar Croatian Society of Medical Biochemistry and Laboratory Medicine
M. Koshiba Japan Society of Clinical Chemistry (JSCC)
R. Kumar Gupta Nepal Association for Medical Laboratory Science (NAMLS)
S. Lapin Association of Laboratory Specialists and Organizations
«Federation of laboratory medicine» (FLM)
E. Sertoglu Turkish Biochemical Society (TBS)
A. Tebo American Association for Clinical Chemistry (AACC)
T. Trenti Italian Society of Clinical Chemistry and Clinical Molecular Biology (SIBioC)


Committee Chair's contact

Dr. Joanna SHELDON
Protein Reference Unit St. George's Hospital
Blackshaw Road
London SW17 0NH
Tel.: +44 (0) 208 725 5752
Fax: +44 (0) 208 725 0025

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